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Submit ReviewNFAT Inhibitor
说明： Inhibitor of calcineurin-mediated NFAT activation
别名： VIVIT peptide
纯度： ≥95% (HPLC)
生物活性 for NFAT Inhibitor
NFAT Inhibitor is a selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). Does not disrupt other calcineurin-dependent pathways. Inhibits NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells.
技术数据 for NFAT Inhibitor
| 分子量 | 1683.94 |
| 公式 | C75H118N20O22S |
| 序列 | MAGPHPVIVITGPHEE |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 249537-73-3 |
| PubChem ID | 16135717 |
| InChI Key | QPMHUXBSHGAVGD-MCDIZDEASA-N |
| Smiles | [H]N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for NFAT Inhibitor
| 溶解性 | Soluble to 2 mg/ml in water |
产品说明书 for NFAT Inhibitor
参考文献 for NFAT Inhibitor
参考文献是支持产品生物活性的出版物。
Aramburu et al (1999) Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science 285 2129 PMID: 10497131
Nagamoto-Combs and Combs (2010) Microglial phenotype is regulated by activity of the transcription factor, NFAT (Nuclear Factor of Activated T Cells). J.Neurosci. 30 9641 PMID: 20631193
Roehrl et al (2004) Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc.Natl.Acad.Sci. 101 7554
If you know of a relevant reference for NFAT Inhibitor, please let us know.
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关键词: NFAT Inhibitor, NFAT Inhibitor supplier, NFAT, Inhibitor, VIVIT, peptide, inhibits, inhibitors, calcineurin, calcineurin-mediated, dephosphorylation, nuclear, factor, of, activated, T, cells, Protein, Ser/Thr, Phosphatases, 3930, Tocris Bioscience
2 篇 NFAT Inhibitor 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NFAT Inhibitor 的部分引用包括：
Bradley J et al (2019) Intracellular Ca2+ Homeostasis and Nuclear Export Mediate Exit from Naive Pluripotency. Cell Stem Cell 25 210-224.e6 PMID: 31104942
Noren et al (2016) Endothelial cells decode VEGF-mediated Ca2+ signaling patterns to produce distinct functional responses. Sci Signal 9 ra20 PMID: 26905425
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