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Submit ReviewNGB 2904
说明： Potent and selective D3 antagonist
化学名： N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide
纯度： ≥98% (HPLC)
生物活性 for NGB 2904
NGB 2904 is a potent and selective dopamine D3 receptor antagonist (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). Potently antagonizes quinpirole-stimulated mitogenesis (IC50 = 6.8 nM). Attenuates cocaine's rewarding effects and inhibits relapse to drug-seeking behavior.
化合物库 for NGB 2904
NGB 2904 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for NGB 2904
| 分子量 | 530.92 |
| 公式 | C28H29Cl2N3O.HCl |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 189061-11-8 |
| PubChem ID | 19366304 |
| InChI Key | PFIWYJNBKGCVFM-UHFFFAOYSA-N |
| Smiles | Cl.ClC1=C(Cl)C(=CC=C1)N1CCN(CCCCNC(=O)C2=CC=C3C(CC4=CC=CC=C34)=C2)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for NGB 2904
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 13.27 | 25 | |
| ethanol | 2.65 | 5 |
制备储备液 for NGB 2904
以下数据基于产品分子量 530.92。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 7.53 mL | 37.67 mL | 75.34 mL |
| 1.25 mM | 1.51 mL | 7.53 mL | 15.07 mL |
| 2.5 mM | 0.75 mL | 3.77 mL | 7.53 mL |
| 12.5 mM | 0.15 mL | 0.75 mL | 1.51 mL |
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产品说明书 for NGB 2904
参考文献 for NGB 2904
参考文献是支持产品生物活性的出版物。
Yuan et al (1998) NGB 2904 and NGB 2849: two highly selective DA D3 receptor antagonists. Bioorg.Med.Chem.Lett. 8 2715 PMID: 9873609
Xi et al (2006) The novel DA D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats. Neuropsychopharmacology 31 1393 PMID: 16205781
Pritchard et al (2007) The DA D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion. Pharmacol.Biochem.Behav. 86 718 PMID: 17408730
If you know of a relevant reference for NGB 2904, please let us know.
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关键词: NGB 2904, NGB 2904 supplier, Potent, selective, D3, antagonists, Dopamine, Receptors, dopaminergic, NGB2904, 2635, Tocris Bioscience
2 篇 NGB 2904 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NGB 2904 的部分引用包括：
Nagata et al (2019) Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells. Sci Rep 9 16438 PMID: 31712714
Axel et al (2010) Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and DA D1 receptor pathways in the diet-induced obese rat. Neuropsychopharmacology 35 1464 PMID: 20200509
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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