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NGD 98-2 hydrochloride

Cat. No. 4315 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： High affinity CRF1 antagonist
化学名： N-(1-Ethylpropyl)-3-methoxy-5-[2-methoxy-4-(trifluoromethoxy)phenyl]-6-methyl-2-pyrazinamine hydrochloride
纯度： ≥98% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for NGD 98-2 hydrochloride

NGD 98-2 hydrochloride is a high affinity antagonist of corticotropin-releasing factor receptor 1 (CRF1) (Ki = 1 nM). Orally available and brain penetrant.

技术数据 for NGD 98-2 hydrochloride

分子量 435.87
公式 C19H24F3N3O3.HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
PubChem ID 90488929
InChI Key KUZDADGRZQAQGN-UHFFFAOYSA-N
Smiles CC1=NC(NC(CC)CC)=C(OC)N=C1C2=CC=C(OC(F)(F)F)C=C2OC.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for NGD 98-2 hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for NGD 98-2 hydrochloride

参考文献是支持产品生物活性的出版物。

Hodgetts et al (2011) Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active cortico. releasing factor-1 (CRF-1) receptor antagonist. J.Med.Chem. 54 4187 PMID: 21618986

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关键词: NGD 98-2 hydrochloride, NGD 98-2 hydrochloride supplier, NGD982, corticotrophin, corticotropin-release, releasing, factor, receptors, antagonists, CFR-1, CRF1, high, affinity, Receptors, 4315, Tocris Bioscience

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