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NGI 1

Cat. No. 6652 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Oligosaccharyltransferase (OST) inhibitor; anti-flaviviral
化学名： 5-[(Dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)benzamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NGI 1

NGI 1 is an oligosaccharyltransferase (OST) inhibitor; anti-flaviviral. Inhibits dengue, Zika, West Nile, and yellow fever viruses by blocking viral RNA replication (EC50 values are 0.85 and 2.2 μM for DENV and ZIKV inhibition, respectively). Selectively arrests proliferation of non-small-cell lung cancer cells that are dependent on EGFR or FGFR for survival.

化合物库 for NGI 1

NGI 1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for NGI 1

分子量 394.51
公式 C17H22N4O3S2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 790702-57-7
PubChem ID 2519269
InChI Key QPKGRLIYJGBKJL-UHFFFAOYSA-N
Smiles CN(S(=O)(C1=CC(C(NC2=NC=C(S2)C)=O)=C(N3CCCC3)C=C1)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NGI 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 39.45 100

制备储备液 for NGI 1

以下数据基于产品分子量 394.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.67 mL 25.35 mL
5 mM 0.51 mL 2.53 mL 5.07 mL
10 mM 0.25 mL 1.27 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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参考文献 for NGI 1

参考文献是支持产品生物活性的出版物。

Puschnik et al (2017) A small molecule oligosaccharyltransferase inhibitor with pan-flaviviral activity. Cell Rep. 21 3032 PMID: 29241533

Lopez-Sambrooks et al (2018) Oligosaccharyltransferase inhibition overcomes therapeutic resistance to EGFR tyrosine kinase inhibitors. Cancer Res. 78 5094 PMID: 30026325

Lopez-Sambrooks et al (2016) Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat.Chem.Biol. 12 1023 PMID: 27694802

If you know of a relevant reference for NGI 1, please let us know.

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关键词: NGI 1, NGI 1 supplier, NGI1, Oligosaccharyltransferases, OST, inhibitors, inhibits, antiflaviviral, dengue, Zika, West, Nile, yellow, fever, viruses, blocks, viral, RNA, replication, Other, Transferases, Flaviviruses, 6652, Tocris Bioscience

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