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NHI 2

Cat. No. 5363 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： LDHA inhibitor
化学名： Methyl 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NHI 2

NHI 2 is an LDHA inhibitor; reduces lactate production in HeLa cells. Inhibits cell growth of LPC006 and PANC-1 cells in vitro. Enhances the antiproliferative effects of Gemcitabine (Cat. No. 3259) on LPC006 and PANC-1 cells. Also inhibits ferroptosis.

化合物库 for NHI 2

NHI 2 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for NHI 2

分子量 335.28
公式 C17H12F3NO3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1269802-97-2
PubChem ID 51355147
InChI Key YPPFWRWCZNXINO-UHFFFAOYSA-N
Smiles ON2C1=CC(C3=CC=CC=C3)=CC(C(F)(F)F)=C1C=C2C(OC)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NHI 2

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 33.53 100
ethanol 33.53 100

制备储备液 for NHI 2

以下数据基于产品分子量 335.28。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.98 mL 14.91 mL 29.83 mL
5 mM 0.6 mL 2.98 mL 5.97 mL
10 mM 0.3 mL 1.49 mL 2.98 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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产品说明书 for NHI 2

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for NHI 2

参考文献是支持产品生物活性的出版物。

Maftouh et al (2014) Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcit. against pancreatic cancer cells in hypoxia. Br.J.Cancer 110 172 PMID: 24178759

Calvaresi et al (2013) Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor. Chembiochem 14 2263 PMID: 24174263

Granchi et al (2013) Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds. Org.Biomol.Chem. 11 6588 PMID: 23986182

Jacobsen et al (2018) APD-containing cyclolipodepsipeptides target mitochondrial function in hypoxic cancer cells. Cell Chem.Biol. 25 1337 PMID: 30122371

If you know of a relevant reference for NHI 2, please let us know.

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关键词: NHI 2, NHI 2 supplier, NHI2, C17H12F3NO3, LDHA, inhibitors, lactate, dehydrogenases, antiproliferative, inhibits, Lactate, Dehydrogenase, A, 5363, Tocris Bioscience

1 篇 NHI 2 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NHI 2 的部分引用包括：

Jung-Hee et al (2021) Akt-mediated Ephexin1-Ras interaction promotes oncogenic Ras signaling and colorectal and lung cancer cell proliferation. Cell Death Dis 12 1013 PMID: 34711817

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