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Submit ReviewNI 42
说明： High affinity BRPF inhibitor
化学名： 4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide
纯度： ≥98% (HPLC)
生物活性 for NI 42
NI 42 is a high affinity BRPF inhibitor (Kd values are 40, 210 and 943 nM for BRPF1B, 2 and 3, respectively). Also exhibits modest activity at BRD9 (Kd = 1130 nM). Exhibits selectivity for BRPF over 44 other bromodomains. Orally bioavailable.
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. NI 42 is listed on the Chemical Probes website.
技术数据 for NI 42
| 分子量 | 353.39 |
| 公式 | C18H15N3O3S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1884640-99-6 |
| PubChem ID | 118933132 |
| InChI Key | BMVCSXFOQPYKKC-UHFFFAOYSA-N |
| Smiles | O=S(C1=CC=C(C#N)C=C1)(NC2=CC=C(N(C)C(C(C)=C3)=O)C3=C2)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for NI 42
参考文献 for NI 42
参考文献是支持产品生物活性的出版物。
Igoe et al (2017) Design of a biased potent small molecule inhibitor of the bromodomain and PHD finger-containing (BRPF) proteins suitable for cellular and in vivo studies. J.Med.Chem PMID: 28068087
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关键词: NI 42, NI 42 supplier, NI42, Bromodomains, PHD, fingers, BRPF, inhibitors, inhibits, orally, available, 5786, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
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