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Nicorandil

Cat. No. 2147 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2147 has been discontinued.

View all Inward Rectifier Potassium (K<sub>ir</sub>) Channels products.
说明： Kir6 (KATP) channel opener and NO donor
化学名： N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide
说明书
引用文献 (1)
评论 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Nicorandil

Kir6 (KATP) channel opener and NO donor; antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing Kir6 channels (EC50 values are 10 and > 500 μM respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning.

技术数据 for Nicorandil

分子量 211.18
公式 C8H9N3O4
储存 Desiccate at +4°C
CAS Number 65141-46-0
PubChem ID 47528
InChI Key LBHIOVVIQHSOQN-UHFFFAOYSA-N
Smiles [O-][N+](=O)OCCNC(=O)C1=CC=CN=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Nicorandil

参考文献是支持产品生物活性的出版物。

Shindo et al (1998) SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil. Br.J.Pharmacol. 124 985 PMID: 9692785

Horinaka et al (2001) Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat. J.Cardiovasc.Pharmacol. 38 200 PMID: 11483869

Gomma et al (2001) Potassium channel openers in myocardial ischaemia: therapeutic potential of nicorandil. Drugs 61 1705 PMID: 11693460

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关键词: Nicorandil, Nicorandil supplier, KATP, channel, openers, NO, donor, Potassium, KIR, Channels, Inward, Rectifier, K+, ROS, Donors, Precursors, Nitric, Oxide, Signaling, Signalling, Kir6, rectifier, /, 2147, Tocris Bioscience

1 篇 Nicorandil 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Nicorandil 的部分引用包括：

Killeen et al (2008) Effects of potassium channel openers in the isolated perfused hypokalaemic murine heart. Acta Physiol (Oxf) 193 25 PMID: 18005217

Nicorandil 的评论

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Nicorandil was used to study Kca1.1 channels.
By Sadequl Islam on 11/27/2018
分析类型： In Vitro
种属： Human

Nicorandil was used to study Kca1.1 channels which are are voltage-gated potassium channels that conduct large amounts of potassium ions (K+) across the cell membrane. To understand neuronal excitability modulated by BK channel opening, Nicorandil was introduced into the cell line.

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