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NIKi

Cat. No. 7136 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent NIK inhibitor
化学名： 4-[3-[2-Amino-5-(2-methoxyethoxy)-4-pyrimidinyl]-1H-indol-5-yl]-2-methyl-3-butyn-2-ol
纯度： ≥98%
说明书
引用文献
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NIKi

NIKi is a potent inhibitor of NF-κB-inducing kinase (NIK) activity (IC50 = 20 nM).

技术数据 for NIKi

分子量 366.42
公式 C20H22N4O3
储存 Store at -20°C
纯度 ≥98%
CAS Number 1202763-91-4
PubChem ID 58221375
InChI Key ZZIZLABGKZWVAW-UHFFFAOYSA-N
Smiles COCCOC1=CN=C(N=C1C2=CNC3=CC=C(C#CC(C)(O)C)C=C23)N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NIKi

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.64 100

制备储备液 for NIKi

以下数据基于产品分子量 366.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.73 mL 13.65 mL 27.29 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
10 mM 0.27 mL 1.36 mL 2.73 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for NIKi

参考文献是支持产品生物活性的出版物。

Li et al (2013) Inhibiting NF-κB-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures. Bioorg.Med.Chem.Lett. 23 1238 PMID: 23374866

If you know of a relevant reference for NIKi, please let us know.

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关键词: NIKi, NIKi supplier, potent, NF-κB, nf-kappab, nf-κb, blocks, inhibitors, inhibits, nuclear, factor, kappa, B, anti-inflammatory, antitumor, antitumour, NF-kB/IkB, 7136, Tocris Bioscience

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Pathways for NIKi

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.