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NKY 80

Cat. No. 5071 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Adenylyl cyclase inhibitor
化学名： 2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NKY 80

NKY 80 is an inhibitor of adenylyl cyclase (AC). Exhibits greater affinity for AC5 over AC3 and AC2 (IC50 values are 8.3 μM, 132 μM and 1.7 mM respectively).

化合物库 for NKY 80

NKY 80 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for NKY 80

分子量 229.23
公式 C12H11N3O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 299442-43-6
PubChem ID 2772368
InChI Key SOJUSNIBPPMLCC-UHFFFAOYSA-N
Smiles NC(N=C2)=NC1=C2C(CC(C3=CC=CO3)C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NKY 80

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 22.92 100
ethanol 2.29 10 温和加热

制备储备液 for NKY 80

以下数据基于产品分子量 229.23。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.36 mL 21.81 mL 43.62 mL
5 mM 0.87 mL 4.36 mL 8.72 mL
10 mM 0.44 mL 2.18 mL 4.36 mL
50 mM 0.09 mL 0.44 mL 0.87 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for NKY 80

参考文献是支持产品生物活性的出版物。

Onda et al (2001) Type-specific regulation regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms. J.Biol.Chem. 276 47785 PMID: 11602596

Pierre et al (2009) Capturing adenylyl cyclases as potential drug targets. Nat.Rev.Drug Discov. 8 321 PMID: 19337273

If you know of a relevant reference for NKY 80, please let us know.

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关键词: NKY 80, NKY 80 supplier, NKY80, adenylyl, cyclase, adenylate, inhibitors, inhibits, Adenylyl, Cyclase, 5071, Tocris Bioscience

1 篇 NKY 80 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NKY 80 的部分引用包括：

Jun et al (2020) In Vivo Imaging of the Coupling between Neuronal and CREB Activity in the Mouse Brain. Neuron 105 799-812.e5 PMID: 31883788

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