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NNC 26-9100

Cat. No. 2440 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective sst4 agonist
化学名： 1-[3-[N-(5-Bromopyridin-2-yl)-N-(3,4-dichlorobenzyl)amino]propyl]-3-[3-(1H-imidazol-4-yl)propyl]thiourea
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NNC 26-9100

NNC 26-9100 is a somatostatin sst4 receptor agonist that displays > 100-fold selectivity over sst2 receptors (Ki values are 6 and 621 nM for sst4 and sst2 receptors respectively). Potently inhibits forskolin-induced cAMP accumulation (EC50 = 26 nM).

化合物库 for NNC 26-9100

NNC 26-9100 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for NNC 26-9100

分子量 556.35
公式 C22H25N6Cl2SBr
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 199522-35-5
PubChem ID 9893924
InChI Key UREJDUPKGMFJRU-UHFFFAOYSA-N
Smiles ClC1=C(Cl)C=C(CN(CCCNC(=S)NCCCC2=CNC=N2)C2=CC=C(Br)C=N2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NNC 26-9100

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 27.82 50
ethanol 27.82 50

制备储备液 for NNC 26-9100

以下数据基于产品分子量 556.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 3.59 mL 17.97 mL 35.95 mL
2.5 mM 0.72 mL 3.59 mL 7.19 mL
5 mM 0.36 mL 1.8 mL 3.59 mL
25 mM 0.07 mL 0.36 mL 0.72 mL

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产品说明书 for NNC 26-9100

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for NNC 26-9100

参考文献是支持产品生物活性的出版物。

Liu et al (1998) Nonpeptide somatostatin agonists with sst4 selectivity: synthesis and structure-activity relationships of thioureas. J.Med.Chem. 41 4693 PMID: 9822540

Liu et al (1999) 2-pyridylthioureas: novel nonpeptide somatostatin agonists with SST4 selectivity. Curr.Pharm.Des. 5 255 PMID: 10101224

If you know of a relevant reference for NNC 26-9100, please let us know.

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关键词: NNC 26-9100, NNC 26-9100 supplier, Selective, sst4, agonists, Receptors, Somatostatin, NNC269100, 2440, Tocris Bioscience

1 篇 NNC 26-9100 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NNC 26-9100 的部分引用包括：

Honda et al (2012) Inhibitory effect of somatostatin receptor subtype-4 agonist NNC 26-9100 on micturition reflex in rats. Urology 80 1391000000000 PMID: 22951005

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