Nocodazole

Name: Nocodazole
Brand: Tocris Bioscience
SKU: 1228
Rating: 5 (1 reviews)

Cat. No. 1228 12 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Microtubule inhibitor

化学名： [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]carbonic acid, methyl ester

纯度： ≥95% (HPLC)

说明书

引用文献 (12)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Nocodazole

Nocodazole is a microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion. Enhances homology-directed repair (HDR) efficiency 9 to 31% (depending on cell cycle phase) and increases Cas9-mediated gene editing frequencies.

技术数据 for Nocodazole

分子量	301.32
公式	C₁₄H₁₁N₃O₃S
储存	Store at RT
纯度	≥95% (HPLC)
CAS Number	31430-18-9
PubChem ID	4122
InChI Key	KYRVNWMVYQXFEU-UHFFFAOYSA-N
Smiles	COC(=O)NC1=NC2=CC(=CC=C2N1)C(=O)C1=CC=CS1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Nocodazole

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	15.07	50

制备储备液 for Nocodazole

以下数据基于产品分子量 301.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	6.64 mL	33.19 mL	66.37 mL
2.5 mM	1.33 mL	6.64 mL	13.27 mL
5 mM	0.66 mL	3.32 mL	6.64 mL
25 mM	0.13 mL	0.66 mL	1.33 mL

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产品说明书 for Nocodazole

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Nocodazole

参考文献是支持产品生物活性的出版物。

Vasquez et al (1997) Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro. Mol.Biol.Cell 8 973 PMID: 9201709

Webb et al (2004) Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases. Int.J.Biochem.Cell Biol. 36 2541 PMID: 15325591

Mizushima et al (2010) Methods in mammalian autophagy research. Cell 140 313 PMID: 20144757

Lin et al (2014) Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery. Elife 3 e04766 PMID: 25497837

If you know of a relevant reference for Nocodazole, please let us know.

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关键词: Nocodazole, Nocodazole supplier, Microtubule, inhibitors, inhibits, Tau, Tubulin, Microtubules, Mitosis, crispr, cas9, homology-directed, repair, HDR, Autophagy, CRISPR, Reagents, 1228, Tocris Bioscience