Noscapine hydrochloride

Discontinued Product

1697 has been discontinued.

View all Microtubules products.
说明: Tubulin inhibitor; induces apoptosis
化学名: (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone hydrochloride
纯度: ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)

生物活性 for Noscapine hydrochloride

Noscapine hydrochloride is an opioid alkaloid with several actions. Binds to tubulin, arrests cells in mitosis and induces apoptosis. Antagonist at bradykinin receptors (pA2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues. Modulates IKK activation, suppressing the NF-κB signaling pathway. Blocks proliferation of human leukemia and multiple myeloma cells. Exhibits anti-inflammatory activity.

技术数据 for Noscapine hydrochloride

分子量 449.88
公式 C22H23NO7.HCl
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 912-60-7
PubChem ID 442329
InChI Key MFLVZFXCSKVCSH-URBRKQAFSA-N
Smiles O=C2C1=C(OC)C(OC)=CC=C1[C@]([C@]3([H])N(CCC4=C3C(OC)=C5C(OCO5)=C4)C)([H])O2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

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产品说明书 for Noscapine hydrochloride

关键词: Noscapine hydrochloride, Noscapine hydrochloride supplier, Bradykinin, antagonists, tubulin, inhibitors, inhibits, induces, apoptosis, B1, B2, Receptors, Tau, Microtubules, Mitosis, antitumor, activity, HCl, opioid, alkaloid, 1697, Tocris Bioscience

1 篇 Noscapine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Noscapine hydrochloride 的部分引用包括:

Rennekamp et al (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol 12 552 PMID: 27239788


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Cell Cycle and DNA Damage Research Product Guide

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