Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewNPY 5RA972
说明： Potent and selective NPY Y5 antagonist
化学名： N-[4-Methyl-9-(1-methylethyl)-9H-carbazol-3-yl]-4-morpholinecarboxamide
纯度： ≥98% (HPLC)
生物活性 for NPY 5RA972
Potent and selective neuropeptide Y Y5 receptor antagonist (IC50 values are 3.1, >10000, >10000 and >10000 nM for Y5, Y1, Y2 and Y4 receptors respectively). Does not block NPY-induced feeding in vivo. Orally active and brain penetrant.
技术数据 for NPY 5RA972
| 分子量 | 351.44 |
| 公式 | C21H25N3O2 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 439861-56-0 |
| PubChem ID | 9884833 |
| InChI Key | ZNFMHLDBJPAFEQ-UHFFFAOYSA-N |
| Smiles | CC1=C(NC(N4CCOCC4)=O)C=CC3=C1C2=CC=CC=C2N3C(C)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for NPY 5RA972
参考文献 for NPY 5RA972
参考文献是支持产品生物活性的出版物。
Block et al (2002) Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity. J.Med.Chem. 45 3509 PMID: 12139462
Turnbull et al (2002) Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes 51 2441 PMID: 12145156
Morris et al (2007) Neuropeptide Y suppresses absence seizures in a genetic model primarily through effects on Y receptors. Eur.J.Neurosci. 25 1136 PMID: 17331209
按标靶查看相关产品
按产品操作查看相关产品
关键词: NPY 5RA972, NPY 5RA972 supplier, NPY5RA972, neuropeptide, Y, Y5, receptors, antagonists, potent, selective, NPYY5, neuropeptides, NPY, Receptors, 3677, Tocris Bioscience
1 篇 NPY 5RA972 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NPY 5RA972 的部分引用包括：
Zhang et al (2015) Neuropeptide Y Stimulates Proliferation and Migration of Vascular Smooth Muscle Cells from Pregnancy Hypertensive Rats via Y1 and Y5 Receptors. PLoS One 10 e0131124 PMID: 26131716
NPY 5RA972 的评论
目前没有该产品的评论。 Be the first to review NPY 5RA972 and earn rewards!
Have you used NPY 5RA972?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.