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Submit ReviewNS 11021
说明： KCa1.1 (BK) channel activator
化学名： N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea
纯度： ≥98% (HPLC)
生物活性 for NS 11021
NS 11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Exhibits no modulatory effect on a variety of K+ (KV), Na+ and Ca2+ currents at concentrations <10 μM. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BKCa in open and closed conformations; thought to bind the α subunit.
化合物库 for NS 11021
NS 11021 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for NS 11021
| 分子量 | 511.24 |
| 公式 | C16H9BrF6N6S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 956014-19-0 |
| PubChem ID | 24825677 |
| InChI Key | MDKAFDIKYQMOMF-UHFFFAOYSA-N |
| Smiles | BrC1=CC(C2=NN=NN2)=C(NC(NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=S)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for NS 11021
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| ethanol | 51.12 | 100 | |
| DMSO | 51.12 | 100 |
制备储备液 for NS 11021
以下数据基于产品分子量 511.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.96 mL | 9.78 mL | 19.56 mL |
| 5 mM | 0.39 mL | 1.96 mL | 3.91 mL |
| 10 mM | 0.2 mL | 0.98 mL | 1.96 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.39 mL |
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产品说明书 for NS 11021
参考文献 for NS 11021
参考文献是支持产品生物活性的出版物。
Layne et al (2009) BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle. Am.J.Physiol.Regul.Integr.Comp.Physiol. 298 R378 PMID: 19923353
Bentzen et al (2007) The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels. Mol.Pharmacol. 72 1033 PMID: 17636045
Kun et al (2009) NS11021, a novel opener of large-conductance Ca2+-activated K+ channels, enhances erectile responses in rats. Br.J.Pharmacol. 158 1465 PMID: 19845682
If you know of a relevant reference for NS 11021, please let us know.
关键词: NS 11021, NS 11021 supplier, NS11021, NS_11021, BKCa, KCa1.1, large-conductance, Ca2+-activated, Ca2+-dependent, calcium, potassium, K+, channels, activators, activates, openers, opens, Ca2+-Activated, Potassium, Channels, 4788, Tocris Bioscience
2 篇 NS 11021 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NS 11021 的部分引用包括：
Peter C et al (2022) FMRP Sustains Presynaptic Function via Control of Activity-Dependent Bulk Endocytosis. J Neurosci 42 1618-1628 PMID: 34996816
Bellono (2017) Molecular basis of ancestral vertebrate electroreception. Nature 543 391 PMID: 28264196
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NS 11021 的评论
平均评分: 5 (基于 2 条评论。)
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The pharmacological inhibitors for electrophysiology assay.
By
Anonymous on 02/28/2020
分析类型： In Vitro
种属： Other
The following concentrations we were used:1 μM Bay K, 10 μM nifedipine, 10 μM nimodipine, 300 nM omega -agatoxin, 1 μM omega -conotoxin, 5 μM mibefradil, 1 μM tetrodotoxin, 1 μM charybdotoxin, 100 nM iberiotoxin, 10 μM NS11021.
Great standard calcium activated potassium channel activator for K+ activation experiments.
By
Farzana Islam on 10/06/2018
分析类型： In Vitro
种属： Human
NS 11021 was used as a standard BK channel opener as it is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). It performed well under lab conditions. Needs to be dissolved in organic solvent, ethanol and DMSO are good options for that.
