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NS 19504

Cat. No. 5276 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： KCa1.1 (BK) channel activator
化学名： 5-[(4-Bromophenyl)methyl]-2-thiazolamine
纯度： ≥99% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NS 19504

NS 19504 is a selective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1) (EC50 = 11 μM). Activates BK channels in native smooth muscle cells from guinea pig bladder and reduces spontaneous phasic contractions in bladder strips ex vivo. Displays no effect on contractions induced by a high K+ concentration or at 65 other receptors tested, including L- and N- type Ca2+ channels, Nav, KATP and hERG channels.

化合物库 for NS 19504

NS 19504 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for NS 19504

分子量 269.16
公式 C10H9BrN2S
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 327062-46-4
PubChem ID 727750
InChI Key HGWLTZOMQZIUBW-UHFFFAOYSA-N
Smiles NC1=NC=C(CC2=CC=C(Br)C=C2)S1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NS 19504

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 26.92 100
ethanol 26.92 100

制备储备液 for NS 19504

以下数据基于产品分子量 269.16。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.72 mL 18.58 mL 37.15 mL
5 mM 0.74 mL 3.72 mL 7.43 mL
10 mM 0.37 mL 1.86 mL 3.72 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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参考文献 for NS 19504

参考文献是支持产品生物活性的出版物。

Nausch et al (2014) NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions. J.Pharmacol.Exp.Ther. 350 520 PMID: 24951278

If you know of a relevant reference for NS 19504, please let us know.

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关键词: NS 19504, NS 19504 supplier, NS19504, activators, large, conductance, calcium, Ca2+-activated, potassium, channels, BKCa,, KCa1.1, Ca2+-Activated, Potassium, Channels, 5276, Tocris Bioscience

篇 NS 19504 的引用文献

引用文献是使用了 Tocris 产品的出版物。

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NS 19504 的评论

平均评分: 4 (Based on 1 Review.)

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Used to study BK channel activation: Product worked nicely, would use again.
By Sadequl Islam on 10/12/2018
分析类型： In Vitro
种属： Mouse

The product is a BK channel opener and it performs well under channel opening conditions.In labs the product was stable, and did extremely well in experimental studies.

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