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NS 2028

Cat. No. 4517 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent soluble guanylyl cyclase (sGC) inhibitor
化学名： 8-Bromo-1H,4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NS 2028

NS 2028 is a potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). Blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA (IC50 values are 17 and 20 nM respectively). Inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).

化合物库 for NS 2028

NS 2028 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for NS 2028

分子量 269.05
公式 C9H5BrN2O3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 204326-43-2
PubChem ID 4551
InChI Key MUDRLQRJCGJJTB-UHFFFAOYSA-N
Smiles BrC1=CC=C(OCC(N23)=NOC3=O)C2=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NS 2028

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 26.91 100
ethanol 5.38 20

制备储备液 for NS 2028

以下数据基于产品分子量 269.05。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.72 mL 18.58 mL 37.17 mL
5 mM 0.74 mL 3.72 mL 7.43 mL
10 mM 0.37 mL 1.86 mL 3.72 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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产品说明书 for NS 2028

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for NS 2028

参考文献是支持产品生物活性的出版物。

von Wantoch Rekowski et al (2010) Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of soluble guanylyl cyclase. Bioorg.Med.Chem. 18 1288 PMID: 20036129

Morbidelli et al (2010) The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability. Am.J.Physiol.Regul.Integr.Comp.Physiol. 298 R824 PMID: 20032260

Olesen et al (1998) Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase. Br.J.Pharmacol. 123 299 PMID: 9489619

If you know of a relevant reference for NS 2028, please let us know.

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关键词: NS 2028, NS 2028 supplier, NS2028, supplier, soluble, guanylyl, cyclase, sGC, cGMP, VEGF, inhibitors, inhibits, potent, antiproliferative, Guanylyl, Cyclase, Other, Nitric, Oxide, 4517, Tocris Bioscience

1 篇 NS 2028 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NS 2028 的部分引用包括：

Ping et al (2019) 17β-Estradiol nongenomically induces vascular endothelial H2S release by promoting phosphorylation of cystathionine γ-lyase. J Biol Chem 294 15577-15592 PMID: 31439665

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