Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewNS 5806
说明： KV4.3 channel activator
化学名： N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]urea
纯度： ≥99% (HPLC)
生物活性 for NS 5806
NS 5806 is a KV4.3 channel activator; mediates the transient outward K+ current (Ito). Increases IKv4.3 peak current amplitude in CHO-K1 cells expressing KV4.3 and KChIP2 (EC50 = 5.3 μM). Inhibits KV1.4-mediated currents independently of KChIP2. Also slows the decay of KV4.2 and KV4.3 currents in the presence of KChIP2.
化合物库 for NS 5806
NS 5806 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for NS 5806
| 分子量 | 574.07 |
| 公式 | C16H8Br2F6N6O |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 426834-69-7 |
| PubChem ID | 11642685 |
| InChI Key | UZWJWROOLOOCPQ-UHFFFAOYSA-N |
| Smiles | BrC1=CC(Br)=CC(C2=NN=NN2)=C1NC(NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for NS 5806
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 57.41 | 100 | |
| ethanol | 28.7 | 50 |
制备储备液 for NS 5806
以下数据基于产品分子量 574.07。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.74 mL | 8.71 mL | 17.42 mL |
| 5 mM | 0.35 mL | 1.74 mL | 3.48 mL |
| 10 mM | 0.17 mL | 0.87 mL | 1.74 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.35 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for NS 5806
参考文献 for NS 5806
参考文献是支持产品生物活性的出版物。
Calloe et al (2009) A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome. Cardiovasc.Res. 81 686 PMID: 19073629
Calloe et al (2010) Differential effects of the transient outward K+ current activator NS5806 in the canine left ventricle. J.Mol.Cell.Cardiol. 48 191 PMID: 19632239
Lundby et al (2010) Effect of the Ito activator NS5806 on cloned Kv4 channels depends on the accessory protein KChIP2. Br.J.Pharmacol. 160 2028 PMID: 20649599
If you know of a relevant reference for NS 5806, please let us know.
关键词: NS 5806, NS 5806 supplier, NS5806, kv4.3, channels, ito, transient, outward, potassium, currents, activators, voltage-gated, voltage-dependent, K+, Voltage-Gated, Potassium, Channels, 4166, Tocris Bioscience
1 篇 NS 5806 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NS 5806 的部分引用包括：
Gonzalez et al (2014) Modulation of the voltage-gated potassium channel (Kv4.3) and the auxiliary protein (KChIP3) interactions by the current activator NS5806. J Biol Chem 289 32201 PMID: 25228688
您是否知道使用了 Tocris NS 5806 的优秀论文？ 请告知我们.
NS 5806 的评论
平均评分: 4 (Based on 1 Review.)
Have you used NS 5806?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
NS 5806 shows channel opening properties and would use this product again.
By
Sadequl Islam on 10/12/2018
分析类型： In Vitro
种属： Human
NS 5806 was studied to understand its channel opening properties. The product was dissolved in DMSO and it showed channel opening properties as expected. Performs well in experimental condition. Would recommend and use again.
