NS 8593 hydrochloride

Name: NS 8593 hydrochloride
Brand: Tocris Bioscience
SKU: 4597
Rating: 5 (1 reviews)

Cat. No. 4597 3 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective negative modulator of K_Ca2 (SK) channels; inhibits SK currents

化学名： N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-amine hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (3)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for NS 8593 hydrochloride

NS 8593 hydrochloride is a selective K_Ca2 (SK) channel negative modulator; inhibits SK channel currents (K_d values are 0.42, 0.6 and 0.73 μM for SK1, SK2 and SK3 respectively at 0.5 μM Ca²⁺). Exhibits selectivity for SK channels over K_Ca1.1 (BK), K_Ca3.1 (IK), K_v, Na_v and Ca_v channels. Inhibits afterhyperpolarization in hippocampal slices.

化合物库 for NS 8593 hydrochloride

NS 8593 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for NS 8593 hydrochloride

分子量	299.8
公式	C₁₇H₁₇N₃.HCl
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	875755-24-1
PubChem ID	71311765
InChI Key	VWEKCDTXUUPBNA-PFEQFJNWSA-N
Smiles	C12=CC=CC=C1N=C(N[C@H]3C(C=CC=C4)=C4CCC3)N2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NS 8593 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	29.98	100
	ethanol	6	20

制备储备液 for NS 8593 hydrochloride

以下数据基于产品分子量 299.8。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.34 mL	16.68 mL	33.36 mL
5 mM	0.67 mL	3.34 mL	6.67 mL
10 mM	0.33 mL	1.67 mL	3.34 mL
50 mM	0.07 mL	0.33 mL	0.67 mL

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产品说明书 for NS 8593 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for NS 8593 hydrochloride

参考文献是支持产品生物活性的出版物。

Strøbaek et al (2006) Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hip Mol.Pharmacol. 70 1771 PMID: 16926279

Sørensen (2008) Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators of small conductance Ca²⁺-activated K⁺ channels. J.Med.Chem. 51 7625 PMID: 18998663

Jenkins et al (2011) Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: pharmacological evidence of deep-pore gating of K_Ca2 channels. Mol.Pharmacol. 79 899 PMID: 21363929

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3 篇 NS 8593 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NS 8593 hydrochloride 的部分引用包括：

Tian et al (2018) Prostaglandin E2 increases migration and proliferation of human glioblastoma cells by activating transient receptor potential melastatin 7 channels. J Cell Mol Med 22 6327 PMID: 30338939

Schmidt et al (2022) Structural mechanism of TRPM7 channel regulation by intracellular magnesium Cell Mol Life Sci 79 225 PMID: 35389104

Yi et al (2020) TRPM7 activation potentiates SOCE in enamel cells but requires ORAI. Cell Calcium 87 102187 PMID: 32146159

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