NSC 632839 hydrochloride

Name: NSC 632839 hydrochloride
Brand: Tocris Bioscience
SKU: 2647
Rating: 5 (1 reviews)

Cat. No. 2647 2 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2647 has been discontinued.

View all Deubiquitinating Enzymes products.

说明： Inhibitor of ubiquitin isopeptidase activity

别名： F6

化学名： 3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (2)

生物活性技术数据说明书参考文献

生物活性 for NSC 632839 hydrochloride

NSC 632839 hydrochloride is an inhibitor of ubiquitin isopeptidase activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC₅₀ values are 15.65 and 16.23 μM in E1A and E1A/C9CN cells respectively).

技术数据 for NSC 632839 hydrochloride

分子量	339.86
公式	C₂₁H₂₁NO.HCl
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	157654-67-6
PubChem ID	5351362
InChI Key	ZOKZLTXPTLIWOJ-BYCVLTJGSA-N
Smiles	O=C(/C(CNC3)=C/C2=CC=C(C)C=C2)/C3=C/C1=CC=C(C)C=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for NSC 632839 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for NSC 632839 hydrochloride

参考文献是支持产品生物活性的出版物。

Aleo et al (2006) Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 66 9235 PMID: 16982768

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2 篇 NSC 632839 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NSC 632839 hydrochloride 的部分引用包括：

Zeng et al (2016) CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection. Nature 7 11364 PMID: 27098497

Ryals et al (2018) The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity. Front Cell Neurosci 12 445 PMID: 30532693