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NSC 663284

Cat. No. 1867 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent, selective Cdc25 phosphatase inhibitor
化学名： 6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione
纯度： ≥99% (HPLC)
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引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NSC 663284

NSC 663284 is a potent, selective inhibitor of Cdc25 dual specificity phosphatases (Ki values are 29, 95 and 89 nM for human Cdc25A, Cdc25B2 and Cdc25C respectively); > 20- and > 450-fold selective over VHR and PTP1B phosphatases respectively. Arrests cells at both G1 and G2/M phase and blocks cdk2 and cdk1 activation. Blocks proliferation of a range of human tumor cell lines (IC50 = 0.2 - 35 μM).

化合物库 for NSC 663284

NSC 663284 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for NSC 663284

分子量 321.76
公式 C15H16ClN3O3
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 383907-43-5
PubChem ID 379077
InChI Key BMKPVDQDJQWBPD-UHFFFAOYSA-N
Smiles ClC1=C(NCCN2CCOCC2)C(=O)C2=NC=CC=C2C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NSC 663284

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 16.1 50
ethanol 16.1 50

制备储备液 for NSC 663284

以下数据基于产品分子量 321.76。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 6.22 mL 31.08 mL 62.16 mL
2.5 mM 1.24 mL 6.22 mL 12.43 mL
5 mM 0.62 mL 3.11 mL 6.22 mL
25 mM 0.12 mL 0.62 mL 1.24 mL

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参考文献 for NSC 663284

参考文献是支持产品生物活性的出版物。

Brisson et al (2005) Redox regulation of cdc25B by cell-active Quinolinediones. Mol.Pharmacol. 68 1810 PMID: 16155209

Lazo et al (2001) Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. J.Med.Chem. 44 4042 PMID: 11708908

Pu et al (2002) Dual G1 and G2 phase inhibition by a novel, selective Cdc25 inhibitor 7-chloro-6-(2-morpholin-4-ylethylamino)-quinoline-5,8-dione. J.Biol.Chem. 277 46877 PMID: 12356752

If you know of a relevant reference for NSC 663284, please let us know.

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关键词: NSC 663284, NSC 663284 supplier, Potent, selective, Cdc25, phosphatase, inhibitors, inhibits, Cyclin-Dependent, Protein, Kinase, Cdk, Kinases, Dual-Specificity, Phosphatases, NSC663284, Phosphatase, Cyclin-dependent, CDK1, Subfamily, 1867, Tocris Bioscience

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