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Submit ReviewNSC 668036 is a Wnt signaling inhibitor. Binds the PDZ domain of the Dishevelled (Dvl) protein. Inhibits proliferation, migration and TGF-β-induced differentiation of fibroblasts in vitro. Reduces severity of pulmonary fibrosis in a mouse model.
NSC 668036 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
分子量 | 460.52 |
公式 | C21H36N2O9 |
储存 | Store at -20°C |
纯度 | ≥98% (HPLC) |
CAS Number | 144678-63-7 |
PubChem ID | 71312060 |
InChI Key | IPICFSFUAKDZEI-AJNGGQMLSA-N |
Smiles | CC([C@@H](C(O)=O)OC([C@@H](NC([C@H](C(C)C)OC([C@@H](NC(OC(C)(C)C)=O)C)=O)=O)C)=O)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 46.05 | 100 | |
ethanol | 46.05 | 100 |
以下数据基于产品分子量 460.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.17 mL | 10.86 mL | 21.71 mL |
5 mM | 0.43 mL | 2.17 mL | 4.34 mL |
10 mM | 0.22 mL | 1.09 mL | 2.17 mL |
50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
参考文献是支持产品生物活性的出版物。
Shan et al (2005) Identification of a specific inhibitor of the dishevelled PDZ domain. Biochemistry 44 15495 PMID: 16300398
Wang et al (2015) Targeted inhibition of disheveled PDZ domain via NSC668036 depresses fibrotic process. Exp.Cell Res. 331 115 PMID: 25445788
If you know of a relevant reference for NSC 668036, please let us know.
关键词: NSC 668036, NSC 668036 supplier, NSC668036, Wnt, signaling, inhibitors, inhibits, PDZ, domain, Dishevelled, Dvl, β, beta-catenin, Other, Signaling, 5813, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 NSC 668036 的部分引用包括:
Ming et al (2022) Recapitulating human cardio-pulmonary co-development using simultaneous multilineage differentiation of pluripotent stem cells. Elife 11 PMID: 35018887
Carr et al (2023) The Wnt pathway protein Dvl1 targets Somatostatin receptor 2 for lysosome-dependent degradation. J.Biol.Chem. 299 104645 PMID: 36965619
Carlos et al (2021) Inhibition of Wnt-β-Catenin Signaling by ICRT14 Drug Depends of Post-Transcriptional Regulation by HOTAIR in Human Cervical Cancer HeLa Cells. Front Oncol 11 729228 PMID: 34778043
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