NSC 668036

Cat. No. 5813 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Wnt signaling inhibitor; binds the PDZ domain of the Dishevelled (Dvl) protein

化学名： N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-alanine-(1S)-1-carboxy-2-methylpropyl ester

纯度： ≥98% (HPLC)

引用文献 (3)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for NSC 668036

NSC 668036 is a Wnt signaling inhibitor. Binds the PDZ domain of the Dishevelled (Dvl) protein. Inhibits proliferation, migration and TGF-β-induced differentiation of fibroblasts in vitro. Reduces severity of pulmonary fibrosis in a mouse model.

化合物库 for NSC 668036

NSC 668036 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for NSC 668036

分子量	460.52
公式	C₂₁H₃₆N₂O₉
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	144678-63-7
PubChem ID	71312060
InChI Key	IPICFSFUAKDZEI-AJNGGQMLSA-N
Smiles	CC([C@@H](C(O)=O)OC([C@@H](NC([C@H](C(C)C)OC([C@@H](NC(OC(C)(C)C)=O)C)=O)=O)C)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NSC 668036

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	46.05	100
	ethanol	46.05	100

制备储备液 for NSC 668036

以下数据基于产品分子量 460.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.17 mL	10.86 mL	21.71 mL
5 mM	0.43 mL	2.17 mL	4.34 mL
10 mM	0.22 mL	1.09 mL	2.17 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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产品说明书 for NSC 668036

分析证书/产品说明书

化学品安全技术说明书

参考文献 for NSC 668036

参考文献是支持产品生物活性的出版物。

Shan et al (2005) Identification of a specific inhibitor of the dishevelled PDZ domain. Biochemistry 44 15495 PMID: 16300398

Wang et al (2015) Targeted inhibition of disheveled PDZ domain via NSC668036 depresses fibrotic process. Exp.Cell Res. 331 115 PMID: 25445788

If you know of a relevant reference for NSC 668036, please let us know.

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关键词: NSC 668036, NSC 668036 supplier, NSC668036, Wnt, signaling, inhibitors, inhibits, PDZ, domain, Dishevelled, Dvl, β, beta-catenin, Other, Signaling, 5813, Tocris Bioscience

3 篇 NSC 668036 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NSC 668036 的部分引用包括：

Carr et al (2023) The Wnt pathway protein Dvl1 targets Somatostatin receptor 2 for lysosome-dependent degradation. J.Biol.Chem. 299 104645 PMID: 36965619

Ming et al (2022) Recapitulating human cardio-pulmonary co-development using simultaneous multilineage differentiation of pluripotent stem cells. Elife 11 PMID: 35018887

Carlos et al (2021) Inhibition of Wnt-β-Catenin Signaling by ICRT14 Drug Depends of Post-Transcriptional Regulation by HOTAIR in Human Cervical Cancer HeLa Cells. Front Oncol 11 729228 PMID: 34778043

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Pathways for NSC 668036

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.