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Submit ReviewNSC 687852
说明： Inhibitor of UCHL5 and USP14
别名： b-AP15
化学名： 3,5-Bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propene-1-yl)-4-piperidone
纯度： ≥97% (HPLC)
生物活性 for NSC 687852
NSC 687852 is an inhibitor of 19S regulatory particle associated deubiquitinating enzymes (DUBs), UCHL5 and USP14. Shows minimal inhibition of UCHL-1, UCHL-3, USP2, USP7, USP, BAP1 and proteasome activity. Induces apoptosis by cathepsin D-dependent caspase-cleavage (IC50 = 0.5 μM). Displays antitumor activity in vivo.
技术数据 for NSC 687852
| 分子量 | 419.39 |
| 公式 | C22H17N3O6 |
| 储存 | Store at +4°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 1009817-63-3 |
| PubChem ID | 5351435 |
| InChI Key | GFARQYQBWJLZMW-JYFOCSDGSA-N |
| Smiles | O=C(/C(CN(C(C=C)=O)C3)=C/C2=CC=C([N+]([O-])=O)C=C2)/C3=C/C1=CC=C([N+]([O-])=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for NSC 687852
参考文献 for NSC 687852
参考文献是支持产品生物活性的出版物。
Berndtsson et al (2009) Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system. Int.J.Cancer 124 1463 PMID: 19089926
D'Arcy et al (2011) Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat.Med. 17 1636 PMID: 22057347
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关键词: NSC 687852, NSC 687852 supplier, NSC687852, 19S, regulatory, particle, associated, deubiquitylating, enzymes, DUBs, apoptosis, UCHL5, USP14, cathepsin, D, dependent, caspase, cleavage, antitumor, b-AP15, Deubiquitinating, Enzymes, Apoptosis, Inducers, 4566, Tocris Bioscience
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