NU 6140

Cat. No. 3301 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Cdk2 inhibitor; also potent inhibitor of aurora kinase A and B

化学名： 4-[[6-(Cyclohexylmethoxy)-1H-purin-2-yl]amino]-N,N-diethylbenzamide

纯度： ≥99% (HPLC)

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for NU 6140

NU 6140 is a cyclin-dependent kinase 2 (cdk2) inhibitor (IC₅₀ values are 0.42 - 1.1 μM). Displays some selectivity for cdk2 (IC₅₀ value = 0.94 μM for cdk4 and >2.3 μM for other cdks). Induces cell-cycle arrest at the G2-M phase. Potentiates the apoptotic effect of taxol (Cat. No. 1097) in HeLa cells; down-regulates the antiapoptotic protein survivin. Also potently inhibits aurora kinases (IC₅₀ values are 0.035 and 0.067 μM for aurora kinase B and A, respectively).

化合物库 for NU 6140

NU 6140 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for NU 6140

分子量	422.52
公式	C₂₃H₃₀N₆O₂
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	444723-13-1
PubChem ID	10202471
InChI Key	XHEQSRJCJTWWAH-UHFFFAOYSA-N
Smiles	O=C(N(CC)CC)C(C=C4)=CC=C4NC1=NC(NC=N2)=C2C(OCC3CCCCC3)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NU 6140

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	42.25	100
	ethanol	42.25	100

制备储备液 for NU 6140

以下数据基于产品分子量 422.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.83 mL	23.67 mL
5 mM	0.47 mL	2.37 mL	4.73 mL
10 mM	0.24 mL	1.18 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

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产品说明书 for NU 6140

分析证书/产品说明书

化学品安全技术说明书

参考文献 for NU 6140

参考文献是支持产品生物活性的出版物。

Pennati et al (2005) Potentiation of PacT.-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol.Cancer.Ther. 4 1328 PMID: 16170024

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987

If you know of a relevant reference for NU 6140, please let us know.

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