NVP ADW 742

Cat. No. 5247 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： ATP-competitive inhibitor of IGF1R

化学名： 5-[3-(Phenylmethoxy)phenyl]-7-[trans-3-(1-pyrrolidinylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

纯度： ≥99% (HPLC)

文献 (2)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for NVP ADW 742

NVP ADW 742 is an ATP-competitive inhibitor of IGF1R (IC₅₀ in the range of 0.1-0.2 μM). Also inhibits c-Kit kinase activity (IC₅₀ in the range of 3-5 μM). Exhibits a synergistic effect with Imatinib (Cat. No. 5906), enhancing the sensitivity of multiple small cell lung cancer cell lines to the chemotherapeutics Etoposide (Cat. No. 1226) and Carboplatin (Cat. No. 2626).

技术数据 for NVP ADW 742

分子量	453.58
公式	C₂₈H₃₁N₅O
储存	Store at -20°C
纯度	≥99% (HPLC)
CAS Number	475488-23-4
PubChem ID	9825149
InChI Key	LSFLAQVDISHMNB-UHFFFAOYSA-N
Smiles	NC1=NC=NC2=C1C(C4=CC(OCC5=CC=CC=C5)=CC=C4)=CN2[C@@H]3C[C@@H](CN6CCCC6)C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NVP ADW 742

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	22.68	50
	ethanol	4.54	10

制备储备液 for NVP ADW 742

以下数据基于产品分子量 453.58。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	4.41 mL	22.05 mL	44.09 mL
2.5 mM	0.88 mL	4.41 mL	8.82 mL
5 mM	0.44 mL	2.2 mL	4.41 mL
25 mM	0.09 mL	0.44 mL	0.88 mL

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产品说明书 for NVP ADW 742

分析证书/产品说明书

化学品安全技术说明书

参考文献 for NVP ADW 742

参考文献是支持产品生物活性的出版物。

Warshamana-Greene et al (2005) The Ins-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. Clin.Cancer Res. 11 1563 PMID: 15746061

Warshamana-Greene et al (2004) The Ins-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor signaling. Mol.Cancer Ther. 3 527 PMID: 15141010

Zhou et al (2011) The Ins-like growth factor-I receptor kinase inhibitor NVP-ADW742 sensitizes medulloblastoma to the effects of chemotherapy. Oncol. Rep. 25 1565 PMID: 21455580

If you know of a relevant reference for NVP ADW 742, please let us know.

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关键词: NVP ADW 742, NVP ADW 742 supplier, NVPADW742, ATP, competitive, inhibitors, inhibits, of, IGF1, receptors, kinases, c-Kit, small, cell, lung, cancer, lines, SCLC, insulin-like, growth, factor-1, receptor, Insulin, and, Receptors, Insulin-like, 5247, Tocris Bioscience

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