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Submit ReviewCarboplatin
Description: DNA cross-linking antitumor agent
Alternative Names: NSC 241240,Paraplatin,JM 8
Chemical Name: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
Purity: ≥99% (HPLC)
Biological Activity for Carboplatin
Carboplatin is an antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Enhances radiation-induced single-strand DNA breakage and displays lower nephrotoxicity than analog cisplatin (Cat. No. 2251).
Technical Data for Carboplatin
| M. Wt | 371.25 |
| Formula | C6H12N2O4Pt |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 41575-94-4 |
| PubChem ID | 10339178 |
| InChI Key | OLESAACUTLOWQZ-UHFFFAOYSA-L |
| Smiles | O=C(C21CCC2)O[Pt-2]([NH3+])([NH3+])OC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Carboplatin
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 9.28 | 25 |
Preparing Stock Solutions for Carboplatin
The following data is based on the product molecular weight 371.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 10.77 mL | 53.87 mL | 107.74 mL |
| 1.25 mM | 2.15 mL | 10.77 mL | 21.55 mL |
| 2.5 mM | 1.08 mL | 5.39 mL | 10.77 mL |
| 12.5 mM | 0.22 mL | 1.08 mL | 2.15 mL |
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Product Datasheets for Carboplatin
References for Carboplatin
References are publications that support the biological activity of the product.
Natarajan et al (1999) Increased DNA-binding activity of cis-1,1-cyclobutanedicarboxylatodiammineplatinum (II) (carboplatin) in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited. Biochem.Pharmacol. 58 1625 PMID: 10535754
Thomas et al (2006) High accumulation of platinum-DNA adducts in strial marginal cells of the cochlea is an early event in cisp. but not carbop. ototoxicity. Mol.Pharmacol. 70 23 PMID: 16569706
Yang et al (1995) Carboplatin enhances the production and persistence of radiation-induced DNA single-strand breaks. Radiation Res. 143 302
If you know of a relevant reference for Carboplatin, please let us know.
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Keywords: Carboplatin, Carboplatin supplier, DNA, cross-linking, antitumor, agent, inhibitors, inhibits, synthesis, Apoptosis, Inducer, Synthesis, NSC241240, chemotherapeutics, NSC, 241240, Paraplatin, JM, 8, Inducers, DNA,, RNA, and, Protein, 2626, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Carboplatin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
3 Citations for Carboplatin
Citations are publications that use Tocris products. Selected citations for Carboplatin include:
Massey (2015) Multiparametric Cell Cycle Analysis Using the Operetta High-Content Imager and Harmony Software with PhenoLOGIC. PLoS One 10 e0134306 PMID: 26218638
Bryant et al (2014) Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers. Cell Death Differ 14 570 PMID: 25104095
Ishiguro et al (2016) Cataloging antineoplastic agents according to their effectiveness against platinum-resistant and platinum-sensitive ovarian carcinoma cell lines. J Transl Sci 2 117 PMID: 27076919
Do you know of a great paper that uses Carboplatin from Tocris? Please let us know.
Reviews for Carboplatin
Average Rating: 4 (Based on 1 Review.)
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Anti-tumor activity assay.
By
Donghee Choi on 01/04/2018
Assay Type: In Vitro
Species: Human
Used in in vitro assay to assess anti-tumor activity in combination with other agents
Literature in this Area
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Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for Carboplatin
