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Submit ReviewNVS MLLT-1
说明： Selective MLLT1/3 inhibitor
化学名： N-[2-[[(2S)-2-Methyl-1-pyrrolidinyl]methyl]-1H-benzimidazol-6-yl]-6-isoquinolinecarboxamide
纯度： ≥98% (HPLC)
生物活性 for NVS MLLT-1
NVS MLLT-1 is a selective inhibitor of YEATS domain of MLLT1 and MLLT3 (IC50 values are 150 and 254 nM for MLLT1 and MLLT3, respectively). It shows selectivity for YEATS2/4 domains and over all bromodomains (CERC2 IC50 > 40 μM).
许可信息
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the NVS MLLT-1 probe summary on the SGC website.
化合物库 for NVS MLLT-1
NVS MLLT-1 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for NVS MLLT-1
| 分子量 | 385.47 |
| 公式 | C23H23N5O |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2561471-13-2 |
| PubChem ID | 155925910 |
| InChI Key | ZRTFTZCKJUNZIU-HNNXBMFYSA-N |
| Smiles | C[C@H]1CCCN1CC2=NC3=CC=C(C=C3N2)NC(C4=CC5=C(C=NC=C5)C=C4)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for NVS MLLT-1
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 38.55 | 100 | |
| ethanol | 19.27 | 50 |
制备储备液 for NVS MLLT-1
以下数据基于产品分子量 385.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.59 mL | 12.97 mL | 25.94 mL |
| 5 mM | 0.52 mL | 2.59 mL | 5.19 mL |
| 10 mM | 0.26 mL | 1.3 mL | 2.59 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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产品说明书 for NVS MLLT-1
参考文献 for NVS MLLT-1
参考文献是支持产品生物活性的出版物。
Ni et al (2021) Structure and inhibitor binding characterization of oncogenic MLLT1 mutants. ACS Chem.Biol. 16 571 PMID: 33749253
If you know of a relevant reference for NVS MLLT-1, please let us know.
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关键词: NVS MLLT-1, NVS MLLT-1 supplier, NVSMLLT-1, inhibitors, inhibits, bromodomains, selective, mixed-lineage, leukemia, translocated, to, 1, MLLT1, MLLLT3, super, elongation, complex, subunit, YEATSdomain, Bromodomains, 7482, Tocris Bioscience
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