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Ogerin

Cat. No. 5722 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective positive allosteric modulator at GPR68
化学名： 2-[4-Amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]benzenemethanol
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ogerin

Ogerin is a selective positive allosteric modulator (PAM) of GPR68 (pEC50 = 6.83), which exhibits selectivity for GPR68 over 58 other GPCRs. Ogerin attenuates contextual-based fear memory in mice.

External Portal Information for Ogerin

Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of Ogerin is reviewed on chemicalprobes.org and the SGC website.

化合物库 for Ogerin

Ogerin is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Ogerin

分子量 307.35
公式 C17H17N5O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1309198-71-7
PubChem ID 56707820
InChI Key MDGIEDNDSFMSLP-UHFFFAOYSA-N
Smiles NC1=NC(NCC2=CC=CC=C2)=NC(C3=CC=CC=C3CO)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ogerin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.73 100
ethanol 6.15 20

制备储备液 for Ogerin

以下数据基于产品分子量 307.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.54 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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产品说明书 for Ogerin

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Ogerin

参考文献是支持产品生物活性的出版物。

Huang et al (2015) Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature 527 477 PMID: 26550826

If you know of a relevant reference for Ogerin, please let us know.

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关键词: Ogerin, Ogerin supplier, positive, allosteric, modulators, GPR68, selective, learning, memory, PAM, Orphan, 7-TM, Receptors, 5722, Tocris Bioscience

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