Olopatadine hydrochloride

Cat. No. 4241 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： H₁ antagonist; ocular antiallergic agent

化学名： (Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydro-dibenz[b,e]oxepin-2-acetic acid hydrochloride

纯度： ≥99% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Olopatadine hydrochloride

Olopatadine hydrochloride is a histamine H₁ receptor antagonist (K_i = 31.6 nM). Inhibits the release of histamine, prostaglandin D₂ and tryptase in a concentration-dependent manner. Mast cell stabilizer; inhibits mast cell mediator release. Also suppresses inflammation by inhibition of cytokine production.

化合物库 for Olopatadine hydrochloride

Olopatadine hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Olopatadine hydrochloride

分子量	373.87
公式	C₂₁H₂₃NO₃.HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	140462-76-6
PubChem ID	5282402
InChI Key	HVRLZEKDTUEKQH-NOILCQHBSA-N
Smiles	O=C(CC(C=C3)=CC/1=C3OCC(C=CC=C2)=C2C1=C\CCN(C)C)O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Olopatadine hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	28.04	75
	DMSO	37.39	100

制备储备液 for Olopatadine hydrochloride

以下数据基于产品分子量 373.87。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.67 mL	13.37 mL	26.75 mL
5 mM	0.53 mL	2.67 mL	5.35 mL
10 mM	0.27 mL	1.34 mL	2.67 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for Olopatadine hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Olopatadine hydrochloride

参考文献是支持产品生物活性的出版物。

Tamura et al (2007) Olopatidine ameliorates rat experimental cutaneous inflammation by improving skin barrier function. Pharmacology 81 118 PMID: 17962722

Sharif et al (1996) Characterization of the ocular antiallergic and antihistaminic effects of olopatidine (AL-4943A), a novel drug for treating ocular allergic diseases. J.Pharmacol.Exp.Ther. 278 1252 PMID: 8819509

If you know of a relevant reference for Olopatadine hydrochloride, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Histamine H₁ Receptor Antagonists

关键词: Olopatadine hydrochloride, Olopatadine hydrochloride supplier, histamine, H1, antagonists, antihistamines, mast, cell, stabilizers, ocular, antiallergic, Histamine, Receptors, 4241, Tocris Bioscience

篇 Olopatadine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Olopatadine hydrochloride 的引用文献。您是否知道使用了 Tocris Olopatadine hydrochloride 的优秀论文？请告知我们.