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说明： Nrf2 activator
化学名： 4-Methyl-5-(2-pyrazinyl)-3H-1,2-dithiole-3-thione
纯度： ≥99% (HPLC)
生物活性 for Oltipraz
Oltipraz is a Nrf2 activator; activates Nrf, which binds to antioxidant response elements (AREs) and induces Phase-I and -II drug-metabolizing enzymes including CYP2B and NQO1. Also increases mRNA levels of multiple hepatic xenobiotic transporters. Elevates expression of genes encoding anti-oxidant and multidrug resistance-associated proteins. Displays chemopreventive activity.
技术数据 for Oltipraz
| 分子量 | 226.34 |
| 公式 | C8H6N2S3 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 64224-21-1 |
| PubChem ID | 47318 |
| InChI Key | CKNAQFVBEHDJQV-UHFFFAOYSA-N |
| Smiles | CC1=C(SSC1=S)C2=CN=CC=N2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Oltipraz
参考文献 for Oltipraz
参考文献是支持产品生物活性的出版物。
Merrell et al (2008) Induction of drug metabolism enzymes and transporters by oltipraz in rats. J.Biochem.Mol.Toxicol. 22 128 PMID: 18418891
Manandhar et al (2007) Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes. Eur J Pharmacol. 577 17 PMID: 17854798
Maher et al (2007) Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology 46 1597 PMID: 17668877
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关键词: Oltipraz, Oltipraz supplier, Nrf2, activators, nuclear, factor-E2-related, factor-2, phase-I, -II, drug-metabolizing, enzymes, transporters, chemopreventive, 5294, Tocris Bioscience
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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