主页 / 细胞生物学 / Signal Transduction / Transcription Factors / Nrf2 / Nrf2 Activators / Oltipraz

Oltipraz

Cat. No. 5294 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Nrf2 activator
化学名： 4-Methyl-5-(2-pyrazinyl)-3H-1,2-dithiole-3-thione
纯度： ≥99% (HPLC)
说明书
引用文献
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Oltipraz

Oltipraz is a Nrf2 activator; activates Nrf, which binds to antioxidant response elements (AREs) and induces Phase-I and -II drug-metabolizing enzymes including CYP2B and NQO1. Also increases mRNA levels of multiple hepatic xenobiotic transporters. Elevates expression of genes encoding anti-oxidant and multidrug resistance-associated proteins. Displays chemopreventive activity.

技术数据 for Oltipraz

分子量 226.34
公式 C8H6N2S3
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 64224-21-1
PubChem ID 47318
InChI Key CKNAQFVBEHDJQV-UHFFFAOYSA-N
Smiles CC1=C(SSC1=S)C2=CN=CC=N2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Oltipraz

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 11.32 50

制备储备液 for Oltipraz

以下数据基于产品分子量 226.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 8.84 mL 44.18 mL 88.36 mL
2.5 mM 1.77 mL 8.84 mL 17.67 mL
5 mM 0.88 mL 4.42 mL 8.84 mL
25 mM 0.18 mL 0.88 mL 1.77 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for Oltipraz

参考文献是支持产品生物活性的出版物。

Merrell et al (2008) Induction of drug metabolism enzymes and transporters by oltipraz in rats. J.Biochem.Mol.Toxicol. 22 128 PMID: 18418891

Manandhar et al (2007) Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes. Eur J Pharmacol. 577 17 PMID: 17854798

Maher et al (2007) Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology 46 1597 PMID: 17668877

If you know of a relevant reference for Oltipraz, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Nrf2 Activators

关键词: Oltipraz, Oltipraz supplier, Nrf2, activators, nuclear, factor-E2-related, factor-2, phase-I, -II, drug-metabolizing, enzymes, transporters, chemopreventive, 5294, Tocris Bioscience

篇 Oltipraz 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Oltipraz 的引用文献。 您是否知道使用了 Tocris Oltipraz 的优秀论文？ 请告知我们.

Oltipraz 的评论

目前没有该产品的评论。 Be the first to review Oltipraz and earn rewards!

Have you used Oltipraz?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.