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Submit ReviewONO 4817
说明： Broad spectrum MMP inhibitor
化学名： N-[(1S,3S)-1-[(Ethoxymethoxy)methyl]-4-(hydroxyamino)-3-methyl-4-oxobutyl]-4-phenoxybenzamide
纯度： ≥99% (HPLC)
生物活性 for ONO 4817
Broad spectrum MMP inhibitor; Ki values are 0.45, 0.73, 1.1, 1.1, 2.1, 42 and 2500 nM for MMP-12, MMP-2, MMP-8, MMP-13, MMP-9, MMP-3 and MMP-7 respectively and IC50 = 1600 nM for MMP-1). Displays no activity at other proteases up to a concentration of 100 μM. Exhibits antiangiogenic and anti-invasive properties on lung metastasis of murine renal cell carcinoma.
技术数据 for ONO 4817
| 分子量 | 416.47 |
| 公式 | C22H28N2O6 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 223472-31-9 |
| PubChem ID | 9888141 |
| InChI Key | HDWWQELUBWGQGA-WMZOPIPTSA-N |
| Smiles | O=C(N[C@H](COCOCC)C[C@H](C)C(NO)=O)C1=CC=C(OC2=CC=CC=C2)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ONO 4817
参考文献 for ONO 4817
参考文献是支持产品生物活性的出版物。
Yamada et al (2000) ONO-4817, an orally active matrix metalloproteinase inhibitor, prevents lipopolysaccharide-induced proteoglycan release from the joint cartilage in guinea pigs. Inflamm.Res. 49 144 PMID: 10858013
Muraishi et al (2001) Effect of a matrix metalloproteinase inhibitor (ONO-4817) on lung metastasis of murine renal cell carcinoma. Anticancer Res. 21 3845 PMID: 11911256
Medina and Radomski (2006) Role of matrix metalloproteinases in intestinal inflammation. J.Pharmacol.Exp.Ther. 318 933 PMID: 16644899
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关键词: ONO 4817, ONO 4817 supplier, Broad, spectrum, MMP, inhibitors, inhibits, Matrixins, Matrix, Metalloproteinase, Metalloprotease, Proteinases, Proteases, ONO4817, 2628, Tocris Bioscience
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Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.