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ONO 8130

Cat. No. 5406 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： EP1 receptor antagonist
化学名： 4-[[[2,3-Dihydro-6-[(2-methylpropyl)[(4-methyl-2-thiazolyl)sulfonyl]amino]-1H-indene-5yl]oxy]methyl]benzoic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ONO 8130

ONO 8130 is an EP1 receptor antagonist. Exhibits analgesic effect in a mouse model of cystitis. Orally bioavailable.

化合物库 for ONO 8130

ONO 8130 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ONO 8130

分子量 500.63
公式 C25H28N2O5S2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 459841-96-4
PubChem ID 9827317
InChI Key IOXMDBQCUCDLAF-UHFFFAOYSA-N
Smiles CC(C)CN(S(C3=NC(C)=CS3)(=O)=O)C1=C(OCC4=CC=C(C(O)=O)C=C4)C=C(CCC2)C2=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ONO 8130

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 50.06 100
ethanol 10.01 20

制备储备液 for ONO 8130

以下数据基于产品分子量 500.63。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2 mL 9.99 mL 19.97 mL
5 mM 0.4 mL 2 mL 3.99 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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参考文献 for ONO 8130

参考文献是支持产品生物活性的出版物。

Miki et al (2011) ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. Pain 152 1373 PMID: 21396778

Lipina et al (2005) Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to cloz. in mouse models of schizophrenia. Psychopharmacology 179 54 PMID: 15759151

If you know of a relevant reference for ONO 8130, please let us know.

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关键词: ONO 8130, ONO 8130 supplier, ONO8130, EP1, receptor, antagonists, antagonism, analgesics, cystitis, Prostanoid, Receptors, 5406, Tocris Bioscience

1 篇 ONO 8130 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ONO 8130 的部分引用包括：

Petra I et al (2022) NR5A2/LRH-1 regulates the PTGS2-PGE2-PTGER1 pathway contributing to pancreatic islet survival and function. iScience 25 104345 PMID: 35602948

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