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Submit ReviewOSU 6162 hydrochloride
说明： Dopamine stabilizer
别名： PNU 96391
化学名： (3S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride
纯度： ≥98% (HPLC)
生物活性 for OSU 6162 hydrochloride
OSU 6162 hydrochloride is a dopamine stabilizer; lacks high affinity for various neuroreceptors in vitro (Ki values are 447 and 1305 nM for D2 and D3 receptors respectively and > 1 μM for other targets). Exhibits high D2 receptor occupancy in vivo; highly active on dopamine synthesis and turnover. Induces stabilizing effects on psychomotor function in behavioral tests without inducing hypolocomotion or catalepsy.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
化合物库 for OSU 6162 hydrochloride
OSU 6162 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for OSU 6162 hydrochloride
| 分子量 | 317.87 |
| 公式 | C15H23NO2S.HCl |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 156907-84-5 |
| PubChem ID | 9836644 |
| InChI Key | LEMGVHZVBREXAD-PFEQFJNWSA-N |
| Smiles | CCCN(C2)CCC[C@@]2([H])C1=CC=CC(S(=O)(C)=O)=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for OSU 6162 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 31.79 | 100 | |
| DMSO | 31.79 | 100 |
制备储备液 for OSU 6162 hydrochloride
以下数据基于产品分子量 317.87。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.15 mL | 15.73 mL | 31.46 mL |
| 5 mM | 0.63 mL | 3.15 mL | 6.29 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.15 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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产品说明书 for OSU 6162 hydrochloride
参考文献 for OSU 6162 hydrochloride
参考文献是支持产品生物活性的出版物。
Nichols et al (2002) PNU-96391A (OSU6162) antagonizes the development of behavioural sensitization induced by DA agonists in a rat model for Parkinson's disease. Neuropharmacology 43 817 PMID: 12384167
Natesan et al (2006) The DA stabilizers (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonyl-phenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low potentia J.Pharmacol.Exp.Ther. 318 810 PMID: 16648369
Rung et al (2005) The DArgic stabilizers (-)-OSU6162 and ACR16 reverse (+)-MK-801-induced social withdrawal in rats. Prog.Neuro-Psychopharm.Biol.Psychiat. 29 833
If you know of a relevant reference for OSU 6162 hydrochloride, please let us know.
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关键词: OSU 6162 hydrochloride, OSU 6162 hydrochloride supplier, Dopamine, stabilizer, Dopaminergic, Receptors, OSU6162, hydrochloride, PNU96391, D2, receptor, PNU, 96391, Dopaminergic-Related, 2599, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.