Ouabain

Cat. No. 1076 9 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Na⁺/K⁺ ATPase inhibitor

化学名： 3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11α,14,19-pentahydoxycard-20(22)-enolide

纯度： ≥95% (HPLC)

引用文献 (9)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Ouabain

Ouabain is a selective Na⁺, K⁺-ATPase inhibitor. Cardiotonic agent. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC₅₀ = 0.08 μM).

技术数据 for Ouabain

分子量	584.66
公式	C₂₉H₄₄O₁₂
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	630-60-4
PubChem ID	439501
InChI Key	LPMXVESGRSUGHW-MJARETDLSA-N
Smiles	O[C@@]12[C@@]3([H])[C@]([C@]([C@H](O)C[C@H](O[C@H]4C(O)C(O)[C@@H](O)[C@H](C)O4)C5)(CO)[C@]5(O)CC3)([H])[C@H](O)C[C@]1(C)[C@@H](C(CO6)=CC6=O)CC2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ouabain

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water		10
	DMSO	58.47	100

制备储备液 for Ouabain

以下数据基于产品分子量 584.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.71 mL	8.55 mL	17.1 mL
5 mM	0.34 mL	1.71 mL	3.42 mL
10 mM	0.17 mL	0.86 mL	1.71 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for Ouabain

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Ouabain

参考文献是支持产品生物活性的出版物。

Croyle et al (1997) Extensive random mutagenesis analysis of the Na/K⁺ ATPase alpha subunit identifies known and previously unidentified amino acid residues that alter ouabain sensitivity-implications for ouabain binding. Eur.J.Biochem. 248 488 PMID: 9346307

Hosoi et al (1997) Isoform-specific up-regulation by ouabain of Na⁺, K⁺-ATPase in cultured rat astrocytes. J.Neurochem. 69 2189 PMID: 9349566

Marjorie et al (1997) Ouabain improves cardiac function in vivo in rats with heart failure after chronic but not acute treatment. Naunyn Schmiedebergs Arch.Pharmacol. 356 203 PMID: 9272726

Merck Index 12 7031

Ko et al (2020) Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. BioRxiv - Paper not yet peer reviewed

If you know of a relevant reference for Ouabain, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Na⁺/K⁺ ATPase Inhibitors

关键词: Ouabain, Ouabain supplier, Na+K+-ATPases, inhibitors, inhibits, Ion, Pumps, Transporters, COVID-19, MERS-CoV, middle, eastern, respiratory, virus, coronavirus, Na+/K+, ATPase, Coronavirus, 1076, Tocris Bioscience