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Submit ReviewOXA (17-33)
说明： Potent and selective peptide OX1 agonist
纯度： ≥95% (HPLC)
生物活性 for OXA (17-33)
OXA (17-33) is a potent and selective peptide orexin OX1 receptor agonist (EC50 values are 8.29 and 187 nM for OX1 and OX2 receptors respectively). Truncated form of orexin A (Cat. No. 1455).
技术数据 for OXA (17-33)
| 分子量 | 1749 |
| 公式 | C79H125N23O22 |
| 序列 |
YELLHGAGNHAAGILTL (Modifications: Leu-33 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 343268-91-7 |
| PubChem ID | 44376806 |
| InChI Key | JPRBZUXULYLVPJ-HYNYKCRDSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for OXA (17-33)
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for OXA (17-33)
参考文献 for OXA (17-33)
参考文献是支持产品生物活性的出版物。
Darker et al (2001) Structure-activity analysis of truncated orexin-A analogues at the orexin-1 receptor. Bioorg.Med.Chem.Lett. 11 737 PMID: 11266181
German et al (2013) Truncated orexin peptides: structure-activity relationship studies. Med.Chem.Lett. 4 1224 PMID: 24707347
If you know of a relevant reference for OXA (17-33), please let us know.
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关键词: OXA (17-33), OXA (17-33) supplier, Potent, selective, orexin, OX1, receptors, agonists, Receptor, 5115, Tocris Bioscience
3 篇 OXA (17-33) 的引用文献
引用文献是使用了 Tocris 产品的出版物。 OXA (17-33) 的部分引用包括：
Feng et al (2012) Involvement of spinal orexin A in the electroacupuncture analgesia in a rat model of post-laparotomy pain. Drug Des Devel Ther 12 225 PMID: 23173601
Kelsey et al (2022) Properties and modulation of excitatory inputs to the locus coeruleus. J Physiol 600 4897-4916 PMID: 36156249
Hugh D et al (2014) Acute suppressive and long-term phase modulation actions of orexin on the mammalian circadian clock. J Neurosci 34 3607-21 PMID: 24599460
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