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说明： USP7 inhibitor
化学名： 1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]ethanone
纯度： ≥99% (HPLC)
生物活性 for P005091
P005091 is a selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 μM). Displays little-to-no inhibition of other USP variants or proteases such as caspase, cathepsins and serine proteases; exhibits some activity at USP47. Induces elevated p53 and apoptosis in cancer cell lines; displays antiangiogenic activity in vivo.
技术数据 for P005091
| 分子量 | 348.22 |
| 公式 | C12H7Cl2NO3S2 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 882257-11-6 |
| PubChem ID | 2819993 |
| InChI Key | LKZLGMAAKNEGCH-UHFFFAOYSA-N |
| Smiles | CC(=O)C1=CC(=C(SC2=CC=CC(Cl)=C2Cl)S1)[N+]([O-])=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for P005091
参考文献 for P005091
参考文献是支持产品生物活性的出版物。
Weinstock et al (2012) Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47. J.Med.Chem. 3 789
Chauhan et al (2012) A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes borte. resistance. Cancer Cell. 22 345 PMID: 22975377
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关键词: P005091, P005091 supplier, ubiquitin-specific, protease, USP7, inhibitors, inhibits, antiangiogenesis, antiangiogenic, apoptosis, p53, Antiangiogenics, Deubiquitinating, Enzymes, 4733, Tocris Bioscience
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