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P1075

Cat. No. 1355 2 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1355 has been discontinued.

View all Inward Rectifier Potassium (K<sub>ir</sub>) Channels products.
说明： Potent Kir6 (KATP) channel opener
化学名： N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridylguanidine
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for P1075

P1075 is a potent Kir6 (KATP) channel opener (EC50 for relaxation of rat aorta = 7.5 nM). Binds to SUR2A and SUR2B with high affinity (Kd values are 17 and 3 nM respectively).

技术数据 for P1075

分子量 231.3
公式 C12H17N5
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 60559-98-0
PubChem ID 43345
InChI Key HKZNADVVGXKQDL-UHFFFAOYSA-N
Smiles CCC(C)(C)\N=C(/NC#N)NC1=CC=CN=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for P1075

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for P1075

参考文献是支持产品生物活性的出版物。

Ashcroft and Gribble (2000) New windows on the mechanism of action of KATP channel openers. TiPS 21 439 PMID: 11121575

Buckner et al (2000) Pharmacological and molecular analysis of ATP-sensitive K+ channels in the pig and human detrusor. Eur.J.Pharmacol. 400 287 PMID: 10988346

Gross et al (1999) Stoichiometry of potassium channel opener action. Mol.Pharmacol. 56 1370 PMID: 10570067

Higdon et al (1997) Tissue and species variation in the vascular receptor binding of 3H-P1075, a potent KATP opener vasodilator. J.Pharmacol.Exp.Ther. 280 255 PMID: 8996204

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关键词: P1075, P1075 supplier, Potent, KATP, channel, openers, Potassium, KIR, Channels, Inward, Rectifier, K+, Kir6, rectifier, 1355, Tocris Bioscience

2 篇 P1075 的引用文献

引用文献是使用了 Tocris 产品的出版物。 P1075 的部分引用包括：

Baczkó et al (2005) Plasma membrane KATP channel-mediated cardioprotection involves posthypoxic reductions in calcium overload and contractile dysfunction: mechanistic insights into cardioplegia. FASEB J 19 980 PMID: 15774423

Cao et al (2005) KATP channel conductance of descending vasa recta pericytes. Am J Physiol Renal Physiol 289 F1235 PMID: 16048905

P1075 的评论

平均评分: 5 (Based on 1 Review.)

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P1075 was used to measure how it affects BK channel modulation.
By Anonymous on 11/28/2018
分析类型： In Vitro
种属： Human

P1075 was used to measure how it affects BK channel modulation. Channel opening was assessed with non radioactive means using Rubidium efflux method.

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