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P7C3

Cat. No. 4076 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： NAMPT activator; also proneurogenic and neuroprotective
化学名： 3,6-Dibromo-α-[(phenylamino)methyl]-9H-carbazole-9-ethanol
纯度： ≥99% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for P7C3

P7C3 is a NAMPT activator. Proneurogenic and neuroprotective. Protects newborn neurons in the dentate gyrus by mitigating cell death. Also enhances learning and memory in aged rats. Orally available and brain penetrant. Also revents doxorubicin-mediated toxicity in osteosarcoma cells and restores intracellular NAD levels.

化合物库 for P7C3

P7C3 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for P7C3

分子量 474.19
公式 C21H18Br2N2O
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 301353-96-8
PubChem ID 2836187
InChI Key FZHHRERIIVOATI-UHFFFAOYSA-N
Smiles BrC(C=C3)=CC1=C3N(CC(O)CNC4=CC=CC=C4)C2=C1C=C(Br)C=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for P7C3

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 47.42 100

制备储备液 for P7C3

以下数据基于产品分子量 474.19。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.11 mL 10.54 mL 21.09 mL
5 mM 0.42 mL 2.11 mL 4.22 mL
10 mM 0.21 mL 1.05 mL 2.11 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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参考文献 for P7C3

参考文献是支持产品生物活性的出版物。

Pieper et al (2010) Discovery of a proneurogenic, neuroprotective chemical. Cell 142 39 PMID: 20603013

Wang et al (2014) P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell 158 1324 PMID: 25215490

If you know of a relevant reference for P7C3, please let us know.

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关键词: P7C3, P7C3 supplier, P7C3, neuroprotective, neurogenesis, proneurogenic, NAMPT, Neural, Stem, Cells, 4076, Tocris Bioscience

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