PA 1 dihydrochloride

Name: PA 1 dihydrochloride
Brand: Tocris Bioscience
SKU: 5463

Cat. No. 5463 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5463 has been discontinued.

View all Photoswitchable Ligands products.

说明： Photoswitchable ENaC blocker

化学名： 3,5-Diamino-6-chloro-N-[imino[[4-(2-phenyldiazenyl)phenyl]amino]methyl]-2-pyrazinecarboxamide dihydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for PA 1 dihydrochloride

Photoswitchable epithelial sodium channel (ENaC) blocker (IC₅₀ values are 90 and 390 nM for αβγ and δβγENaCs, respectively, in the trans conformation). Switches conformation from cis to trans at 500 nm and trans to cis at 400 nm. Blocks ENaCs with greater efficacy in the cis conformation, in comparison to the trans conformation, in Xenopus oocytes and HEK293t cells. Partially blocks δβγENaCs in the trans conformation and exhibits near maximal block of δβγENaCs in the cis conformation. Amiloride derivative.

技术数据 for PA 1 dihydrochloride

分子量	482.75
公式	C₁₈H₁₆ClN₉O.2HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
PubChem ID	121513862
InChI Key	JKZVQNCSFUAMFC-UHFFFAOYSA-N
Smiles	O=C(NC(NC2=CC=C(/N=N/C3=CC=CC=C3)C=C2)=N)C1=C(N)N=C(N)C(Cl)=N1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for PA 1 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PA 1 dihydrochloride

参考文献是支持产品生物活性的出版物。

Schönberger et al (2014) Controlling epithelial sodium channels with light using photoswitchable amilorides. Nat.Chem. 6 712 PMID: 25054942

按标靶查看相关产品

关键词: PA 1 dihydrochloride, PA 1 dihydrochloride supplier, photoswitchable, ENaC, blockers, epithelial, sodium, channels, Na+, photoamiloride-1, PA1, ligands, Photoswitchable, Ligands, Epithelial, Sodium, Channels, 5463, Tocris Bioscience

篇 PA 1 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 PA 1 dihydrochloride 的引用文献。