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说明： Activator of procaspase-3; pro-apoptotic
化学名： 4-(Phenylmethyl)-1-piperazineacetic acid [[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide
纯度： ≥98% (HPLC)
生物活性 for PAC 1
PAC 1 is a procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC50 = 0.22 μM). Also activates procaspase-7 in a less efficient manner (EC50 = 4.5 μM). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC50 values are 0.003 - 1.41 and 5.02 - 9.98 μM respectively).
技术数据 for PAC 1
| 分子量 | 392.5 |
| 公式 | C23H28N4O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 315183-21-2 |
| PubChem ID | 9675990 |
| InChI Key | YQNRVGJCPCNMKT-LFVJCYFKSA-N |
| Smiles | O=C(N/N=C/C3=CC=CC(CC=C)=C3O)CN(CC2)CCN2CC1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PAC 1
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| 1eq. HCl | 29.44 | 75 | |
| DMSO | 39.25 | 100 |
制备储备液 for PAC 1
以下数据基于产品分子量 392.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.74 mL | 25.48 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.1 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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产品说明书 for PAC 1
参考文献 for PAC 1
参考文献是支持产品生物活性的出版物。
Putt et al (2006) Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat.Chem.Biol. 2 543 PMID: 16936720
Peterson et al (2009) Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3. J.Med.Chem. 52 5721 PMID: 19708658
If you know of a relevant reference for PAC 1, please let us know.
按产品操作查看相关产品
关键词: PAC 1, PAC 1 supplier, activators, procaspase-3, proapoptotic, Caspases, Proteinases, Proteases, PAC1, Enzyme, Substrates, /, Activators, 2581, Tocris Bioscience
2 篇 PAC 1 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PAC 1 的部分引用包括：
Chiu et al (2019) NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content. Cell Rep 28 332 PMID: 31291571
Yosefzon et al (2018) Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size. Mol Cell 70 573 PMID: 29775577
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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