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PAMP-20 (human)

Cat. No. 6552 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： MRGPRX2 agonist; also non-competitive nAChR antagonist
纯度： ≥95% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PAMP-20 (human)

PAMP-20 (human) is an endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 251 nM). Also a noncompetitive nicotinic cholinergic antagonist. Inhibits nicotine-stimulated catecholamine secretion from PC12 cells in vitro, and from sympathetic nerve endings and adrenal chromaffin cells in vivo. Corresponds to amino acids 1 - 20 of proadrenomedullin. Antihypertensive.

技术数据 for PAMP-20 (human)

分子量 2460.87
公式 C112H178N36O27
序列 ARLDVASEFRKKWNKWALSR

(Modifications: Arg-20 = C-terminal amide)
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 150238-87-2
PubChem ID 71311703
InChI Key PIRWNASAJNPKHT-SHZATDIYSA-N
Smiles [H]N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PAMP-20 (human)

溶解性 Soluble to 1 mg/ml in water

产品说明书 for PAMP-20 (human)

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参考文献 for PAMP-20 (human)

参考文献是支持产品生物活性的出版物。

Mahata et al (1998) Proadrenomedullin N-terminal 20 peptide: minimal active region to regulate nicotinic receptors. Hypertension 32 907 PMID: 9822452

Kamohara et al (2005) Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem.Biophys.Res.Commun, 330 1146 PMID: 15823563

If you know of a relevant reference for PAMP-20 (human), please let us know.

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关键词: PAMP-20 (human), PAMP-20 (human) supplier, PAMP, n-terminal, 1-20, human, proadrenomedullin, ProAM, N20, Mas, related, GPR, X2, MRGPRX2, agonists, agonism, Mas-related, G, Protein-Coupled, Receptors, Nicotinic, (Non-selective), 6552, Tocris Bioscience

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