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Paprotrain

Cat. No. 4813 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4813 has been discontinued.

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说明： Reversible inhibitor of MKLP-2
化学名： (Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
纯度： ≥99% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for Paprotrain

Paprotrain is a reversible, non-ATP competitive inhibitor of mitotic kinesin-like protein 2 (MKLP-2) (Ki = 3.4 μM). Inhibits the basal ATPase activity of MKLP-2 (IC50 = 1.35 μM). Exhibits selectivity for MKLP-2 over 12 other members of the kinesin superfamily, including the closely-related MKLP-1. Cell permeable.

技术数据 for Paprotrain

分子量 245.28
公式 C16H11N3
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 57046-73-8
PubChem ID 12248889
InChI Key YMYYQRZCCKBFBE-MDWZMJQESA-N
Smiles N#C/C(C3=CNC2=CC=CC=C23)=C\C1=CN=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Paprotrain

参考文献是支持产品生物活性的出版物。

Tcherniuk et al (2010) Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor. Agnew Chem.Int.Ed.Engl. 49 8228 PMID: 20857469

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关键词: Paprotrain, Paprotrain supplier, inhibitors, inhibits, MKLP-2, mitotic, kinesin-like, protein, 2, reversible, selective, Kinesin, 4813, Tocris Bioscience

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