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Submit ReviewPARPi-FL
说明： Potent fluorescent PARP inhibitor; cell permeable
别名： AZD2281-BDY FL,Olaparib-BDY FL
化学名： (T-4)-[4-[[3-[[4-[3-[5-[(3,5-Dimethyl-2H-pyrrol-2-ylidene-κN)methyl]-1H-pyrrol-2-yl-κN-1-oxopropyl]-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinonato]difluoroboron
纯度： ≥90% (HPLC)
生物活性 for PARPi-FL
PARPi-FL is a fluorescent potent PARP inhibitor (IC50 = 12 nM). Composed of a PARP inhibitor conjugated to BDY FL, SE (Cat. No. 5465). Colocalizes with PARP immunostaining in multiple cancer cell lines in vivo and accumulates in tumor cells and tumor associated macrophages. Enables high temporal and subcellular spatial resolution of drug distribution. Emission max = 525 nm. Cell permeable.
Optical Data for PARPi-FL
| Emission Color | Green |
|---|---|
| λabs | 502 nm |
| λem | 510 nm |
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技术数据 for PARPi-FL
| 分子量 | 640.46 |
| 公式 | C34H32BF3N6O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥90% (HPLC) |
| CAS Number | 1380359-84-1 |
| PubChem ID | 70697686 |
| InChI Key | IGUTVNUEFKPBGK-UHFFFAOYSA-N |
| Smiles | CC1=CC(C)=[N+]2C1=CC3=CC=C(N3[B-]2(F)F)CCC(N4CCN(C(C5=CC(CC6=NNC(C7=CC=CC=C67)=O)=CC=C5F)=O)CC4)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PARPi-FL
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 6.4 | 10 |
制备储备液 for PARPi-FL
以下数据基于产品分子量 640.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.61 mL | 78.07 mL | 156.14 mL |
| 0.5 mM | 3.12 mL | 15.61 mL | 31.23 mL |
| 1 mM | 1.56 mL | 7.81 mL | 15.61 mL |
| 5 mM | 0.31 mL | 1.56 mL | 3.12 mL |
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产品说明书 for PARPi-FL
参考文献 for PARPi-FL
参考文献是支持产品生物活性的出版物。
Thurber et al (2013) Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nat.Commun. 4 1504 PMID: 23422672
Thurber et al (2014) Effect of small-molecule modification on single-cell pharmacokinetics of PARP inhibitors. Mol.Cancer Ther. 13 986 PMID: 24552776
Dubach et al (2017) Quantitating drug-target engagement in single cells in vitro and in vivo. Nat.Chem.Biol. 13 168 PMID: 27918558
If you know of a relevant reference for PARPi-FL, please let us know.
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关键词: PARPi-FL, PARPi-FL supplier, fluorescent, PARP, inhibitors, potent, inhibits, poly, ADP, ribose, polymerase, post, translational, modification, TR, -FRET, acceptor, AZD2281-BODIPY, FL, Olaparib-BODIPY, AZD2281-BDY, Olaparib-BDY, AZD2281, bodipy, bdy, Poly(ADP-ribose), Polymerase, Enzyme, Probes, and, Substrates, TR-FRET, FP, Assay, Reagents, 6461, Tocris Bioscience
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Fluorescent Dyes and Probes Research Product Guide
This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:
- Fluorescent Dyes, including dyes for flow cytometry
- Fluorescent Probes and Stains, including our new MitoBrilliantTM mitochondria stains
- Tissue Clearing Kits and Reagents
- Aptamer-based RNA Imaging Reagents
- Fluorescent Probes for Imaging Bacteria
- TSA VividTM Fluorophore Kits
- TSA Reagents for Enhancing IHC, ICC & FISH Signals