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Submit ReviewpCPA methyl ester hydrochloride is a tryptophan hydroxylase inhibitor. Inhibits 5-HT synthesis. Depletes 5-HT levels in orbitofrontal cortex and impairs reversal learning in rats. Methyl ester of p-Chlorophenylalanine (Cat. No. 0938).
pCPA methyl ester hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
分子量 | 250.12 |
公式 | C10H12ClNO2.HCl |
储存 | Store at -20°C |
纯度 | ≥98% (HPLC) |
CAS Number | 14173-40-1 |
PubChem ID | 26531 |
InChI Key | GCBCWTWQAFLKJG-UHFFFAOYSA-N |
Smiles | O=C(C(CC1=CC=C(C=C1)Cl)N)OC.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
water | 25.01 | 100 | |
DMSO | 25.01 | 100 |
以下数据基于产品分子量 250.12。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 4 mL | 19.99 mL | 39.98 mL |
5 mM | 0.8 mL | 4 mL | 8 mL |
10 mM | 0.4 mL | 2 mL | 4 mL |
50 mM | 0.08 mL | 0.4 mL | 0.8 mL |
参考文献是支持产品生物活性的出版物。
Pinto Brod et al (2016) Involvement of monoaminergic system in the antidepressant-like effect of (octylseleno)-xylofuranoside in the mouse tail suspension test. Prog.Neuropsychopharmacol.Biol.Psychiatry. 65 201 PMID: 26596986
Wallace et al (2014) Vort. restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats. Int.J.Neuropsychopharmacol. 17 1695 PMID: 24852131
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关键词: pCPA methyl ester hydrochloride, pCPA methyl ester hydrochloride supplier, tryptophan, hydroxylase, inhibitors, inhibits, serotonin, 5-HT, depletion, depletes, synthesis, Hydroxylases, 5871, Tocris Bioscience
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