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Submit ReviewPD 161570
说明： Selective FGFR inhibitor
化学名： N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
纯度： ≥97% (HPLC)
生物活性 for PD 161570
PD 161570 is a selective FGFR inhibitor (IC50 values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). Inhibits FGFR receptor phosphorylation (IC50 = 622 nM) and growth of A121 cells in vitro.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
化合物库 for PD 161570
PD 161570 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。
技术数据 for PD 161570
| 分子量 | 532.51 |
| 公式 | C26H35Cl2N7O |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 192705-80-9 |
| PubChem ID | 5328135 |
| InChI Key | MKVMEJKNLUWFSQ-UHFFFAOYSA-N |
| Smiles | ClC1=CC=CC(Cl)=C1C3=CC2=CN=C(NCCCCN(CC)CC)N=C2N=C3NC(NC(C)(C)C)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PD 161570
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 53.25 | 100 | |
| ethanol | 53.25 | 100 |
制备储备液 for PD 161570
以下数据基于产品分子量 532.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.88 mL | 9.39 mL | 18.78 mL |
| 5 mM | 0.38 mL | 1.88 mL | 3.76 mL |
| 10 mM | 0.19 mL | 0.94 mL | 1.88 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
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产品说明书 for PD 161570
参考文献 for PD 161570
参考文献是支持产品生物活性的出版物。
Hamby et al (1997) Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors. J.Med.Chem. 40 2296 PMID: 9240345
Batley et al (1998) Inhibition of FGF-1 receptor tyrosine kinase activity by PD 161570, a new protein-tyrosine kinase inhibitor. Life Sci. 62 143 PMID: 9488112
Stevens et al (2003) Thyroid hormone activates fibroblast growth factor receptor-1 in bone. Mol.Endocrinology 17 1751 PMID: 12805413
If you know of a relevant reference for PD 161570, please let us know.
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关键词: PD 161570, PD 161570 supplier, PD161570, selective, FGFR, inhibitors, inhibits, fibroblast, growth, factors, Pfizer, 3724, Tocris Bioscience
3 篇 PD 161570 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PD 161570 的部分引用包括：
Magaña et al (2014) Paracrine effects of embryo-derived FGF4 and BMP4 during pig trophoblast elongation. Dev Biol 387 15 PMID: 24445281
Rodríguez et al (2012) Modulation of pluripotency in the porcine embryo and iPS cells. J Exp Bot 7 e49079 PMID: 23145076
Tomohiro et al (2020) Regulation of NF-kB Signalling Through the PR55β-RelA Interaction in Osteoblasts. In Vivo 34 601-608 PMID: 32111759
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