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Submit ReviewPeroxy Orange 1 is a fluorescent probe for imaging hydrogen peroxide (H2O2); cell permeable. Displays an orange intracellular fluorescence in response to H2O2 signals produced in RAW 264.7 macrophages and A431 cells during immune response and growth factor stimulation, respectively. Excitation wavelength 543 nm, emission between 545 and 750 nm.
Sold under license from the Regents of the University of California
分子量 | 521.41 |
公式 | C32H32BNO5 |
储存 | Store at -20°C |
CAS Number | 1199576-10-7 |
PubChem ID | 44546671 |
InChI Key | KNTNXZHHCPNNGB-UHFFFAOYSA-N |
Smiles | O=C(O1)C2=C(C=CC=C2)C31C4=CC5=C6C(CCCN6CCC5)=C4OC7=C3C=CC(B8OC(C)(C)C(C)(C)O8)=C7 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 5.21 | 10 |
以下数据基于产品分子量 521.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 19.18 mL | 95.89 mL | 191.79 mL |
0.5 mM | 3.84 mL | 19.18 mL | 38.36 mL |
1 mM | 1.92 mL | 9.59 mL | 19.18 mL |
5 mM | 0.38 mL | 1.92 mL | 3.84 mL |
参考文献是支持产品生物活性的出版物。
Dickinson et al (2010) A palette of fluorescent probes with varying emission colors for imaging hydrogen peroxide signaling in living cells. J.Am.Chem.Soc. 132 5906 PMID: 20361787
Dickinson et al (2011) Chemistry and biology of reactive oxygen species in signaling or stress responses. Nat.Chem.Biol. 7 504 PMID: 21769097
Woolley et al (2012) H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling. PLoS ONE 7 PMID: 22807997
If you know of a relevant reference for Peroxy Orange 1, please let us know.
关键词: Peroxy Orange 1, Peroxy Orange 1 supplier, Fluorescent, probe, hydrogen, peroxide, H2O2, po1, po-1, peroxyorange, orange, immune, growth, factor, excitation, wavelength, emission, PO1, Cell, Indicators, and, Sensors, 4944, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 Peroxy Orange 1 的部分引用包括:
Young Taek et al (2016) A single gene of a commensal microbe affects host susceptibility to enteric infection. Nat Commun 7 11606 PMID: 27173141
Jeong et al (2017) Prdx1 (peroxiredoxin 1) deficiency reduces cholesterol efflux via impaired macrophage lipophagic flux. Autophagy 14 120 PMID: 28605287
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