PF 04217903 mesylate

Cat. No. 4239 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Highly selective MET inhibitor

化学名： 4-[1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol mesylate

纯度： ≥98% (HPLC)

引用文献 (3)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PF 04217903 mesylate

PF 04217903 mesylate is a highly selective, high affinity MET inhibitor (K_i = 6-7 nM against wild type c-Met). Displays >1000-fold selectivity for c-Met over a panel of 208 kinases.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for PF 04217903 mesylate

PF 04217903 mesylate is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for PF 04217903 mesylate

分子量	468.49
公式	C₁₉H₁₆N₈O.CH₃SO₃H
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	956906-93-7
PubChem ID	24852079
InChI Key	HBEMHKVWZJTVOC-UHFFFAOYSA-N
Smiles	OCCN1N=CC(C2=CN=C3C(N(CC4=CC=C(N=CC=C5)C5=C4)N=N3)=N2)=C1.CS(=O)(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PF 04217903 mesylate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	46.85	100

制备储备液 for PF 04217903 mesylate

以下数据基于产品分子量 468.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.13 mL	10.67 mL	21.35 mL
5 mM	0.43 mL	2.13 mL	4.27 mL
10 mM	0.21 mL	1.07 mL	2.13 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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产品说明书 for PF 04217903 mesylate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PF 04217903 mesylate

参考文献是支持产品生物活性的出版物。

Eder et al (2009) Novel therapeutic inhibitors of the c-Met signaling pathway in cancer. Clin.Cancer Res. 15 2207 PMID: 19318488

Timofeevski et al (2009) Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors. Biochemistry 48 5339 PMID: 19459657

Underiner et al (2010) Discovery of small molecule c-Met inhibitors: evolution and profiles of clinical candidates. Anticancer Agents Med.Chem. 10 7 PMID: 20015007

Cui et al (2012) Discovery of a novel class of exquisitely selective mesenchymal-epithelial transition factor (c-MET) protein kinase inhibitors and identification of the clinical candidate 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6- J.Med.Chem. 55 8091 PMID: 22924734

If you know of a relevant reference for PF 04217903 mesylate, please let us know.

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3 篇 PF 04217903 mesylate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PF 04217903 mesylate 的部分引用包括：

Bertaux-Skeirik et al (2015) CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation. PLoS Pathog 11 e1004663 PMID: 25658601

Stella E et al (2013) Tuftsin signals through its receptor neuropilin-1 via the transforming growth factor beta pathway. J Neurochem 127 394-402 PMID: 24033337

Leung et al (2017) Blood vessel endothelium-directed tumor cell streaming in breast tumors requires the HGF/C-Met signaling pathway. Oncogene 36 2680 PMID: 27893712

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