PF 04418948

Cat. No. 4818 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective EP₂ receptor antagonist

化学名： 1-(4-Fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid

纯度： ≥98% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PF 04418948

PF 04418948 is a potent prostaglandin E receptor 2 antagonist (PTGER2; EP2; IC₅₀ = 16 nM for human EP₂ receptors), which displays over 2000-fold selectivity for EP₂ receptors over EP₁, EP₃, EP₄, DP₁ amd CRTH₂ receptors and exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 μM. PF 04418948 inhibits PGE₂-induced increases in intracellular cAMP in vitro and reverses PGE₂-invoked relaxation of mouse trachea (IC₅₀ = 2.7 nM).

许可信息

Sold for research purposes under agreement from Pfizer Inc.

External Portal Information for PF 04418948

The Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PF 04418948 is reviewed.

化合物库 for PF 04418948

PF 04418948 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PF 04418948

分子量	409.41
公式	C₂₃H₂₀FNO₅
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1078166-57-0
PubChem ID	25114442
InChI Key	LWJGMYMNSNVCEM-UHFFFAOYSA-N
Smiles	FC(C=C4)=CC=C4C(N(C3)CC3(C(O)=O)COC2=CC1=CC=C(OC)C=C1C=C2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PF 04418948

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	40.94	100

制备储备液 for PF 04418948

以下数据基于产品分子量 409.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.44 mL	12.21 mL	24.43 mL
5 mM	0.49 mL	2.44 mL	4.89 mL
10 mM	0.24 mL	1.22 mL	2.44 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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产品说明书 for PF 04418948

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PF 04418948

参考文献是支持产品生物活性的出版物。

Birrell et al (2013) Selectivity profiling of the novel EP₂ receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP₂ receptor. Br.J.Pharmacol. 168 129 PMID: 22747912

af Forselles et al (2011) In vitro and in vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP₂ receptor antagonist. Br.J.Pharmacol. 164 1847 PMID: 21595651

If you know of a relevant reference for PF 04418948, please let us know.

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