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Submit ReviewPF 04457845
说明： Potent and selective irreversible FAAH inhibitor
化学名： N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide
纯度： ≥98% (HPLC)
生物活性 for PF 04457845
PF 04457845 is a potent and selective irreversible FAAH inhibitor (IC50 = 7.2 nM, which is selective for FAAH over a panel of other serine hydrolases. PF 04457845 exhibits efficacy in a rat inflammatory pain model, and is orally bioavailable and brain penetrant.
许可信息
Sold for research purposes under agreement from Pfizer Inc
External Portal Information for PF 04457845
Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of PF 04457845 is reviewed on chemicalprobes.org and the SGC website.
化合物库 for PF 04457845
PF 04457845 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for PF 04457845
| 分子量 | 455.43 |
| 公式 | C23H20F3N5O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1020315-31-4 |
| PubChem ID | 24771824 |
| InChI Key | BATCTBJIJJEPHM-UHFFFAOYSA-N |
| Smiles | FC(F)(C1=CC=C(N=C1)OC2=CC=CC(/C=C3CCN(C(NC4=CC=CN=N4)=O)CC\3)=C2)F |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PF 04457845
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 45.54 | 100 | |
| ethanol | 9.11 | 20 |
制备储备液 for PF 04457845
以下数据基于产品分子量 455.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.2 mL | 10.98 mL | 21.96 mL |
| 5 mM | 0.44 mL | 2.2 mL | 4.39 mL |
| 10 mM | 0.22 mL | 1.1 mL | 2.2 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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产品说明书 for PF 04457845
参考文献 for PF 04457845
参考文献是支持产品生物活性的出版物。
Ahn et al (2011) Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain. J.Pharmacol.Exp.Ther. 338 114 PMID: 21505060
Johnson et al (2011) Discovery of PF-04457845: a highly potent, orally bioavailable, and selective urea FAAH inhibitor. ACS Med.Chem.Lett. 2 91 PMID: 21666860
If you know of a relevant reference for PF 04457845, please let us know.
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关键词: PF 04457845, PF 04457845 supplier, PF04457845, FAAH, fatty, acid, amide, hydrolase, inhibitors, inhibits, potent, selective, irreversible, orally, bioavailalbe, brain, penetrant, Fatty, Acid, Amide, Hydrolase, (FAAH), 6374, Tocris Bioscience
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