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PF 04620110

Cat. No. 5863 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective DGAT-1 inhibitor; orally bioavailable
化学名： trans-4-[4-(4-Amino-7,8-dihydro-5-oxopyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]cyclohexaneacetic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PF 04620110

PF 04620110 is a potent and selective DGAT-1 inhibitor (IC50 = 19 nM). Exhibits >1000-fold selectivity for DGAT-1 over DGAT-2, and no significant activity against a range of other enzymes, ion channels and receptors. Reduces plasma triglyceride levels in a rat lipid challenge model. Orally bioavailable.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for PF 04620110

PF 04620110 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PF 04620110

分子量 396.44
公式 C21H24N4O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1109276-89-2
PubChem ID 46926360
InChI Key GEVVQZHMFVFGLN-UHFFFAOYSA-N
Smiles O=C1N(C2=CC=C([C@@H]3CC[C@@H](CC(O)=O)CC3)C=C2)CCOC4=NC=NC(N)=C41

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PF 04620110

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 7.93 20

制备储备液 for PF 04620110

以下数据基于产品分子量 396.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 12.61 mL 63.06 mL 126.12 mL
1 mM 2.52 mL 12.61 mL 25.22 mL
2 mM 1.26 mL 6.31 mL 12.61 mL
10 mM 0.25 mL 1.26 mL 2.52 mL

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参考文献 for PF 04620110

参考文献是支持产品生物活性的出版物。

Dow et al (2011) Discovery of PF-04620110, a potent, selective, and orally bioavailable inhibitor of DGAT-1. ACS Med.Chem.Lett. 2 407 PMID: 24900321

If you know of a relevant reference for PF 04620110, please let us know.

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关键词: PF 04620110, PF 04620110 supplier, PF04620110, potent, selective, orally, bioavailable, inhibitors, inhibits, DGAT-1, Diacylglycerol, acyltransferase, O-Acyltransferase, 5863, Tocris Bioscience

1 篇 PF 04620110 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PF 04620110 的部分引用包括：

Jian et al (2020) ABHD5 suppresses cancer cell anabolism through lipolysis-dependent activation of the AMPK/mTORC1 pathway. J Biol Chem 296 100104 PMID: 33219129

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