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Submit ReviewPF 04628935
说明： Potent ghrelin receptor inverse agonist
化学名： 1-[2-[[2-Chloro-4-(2H-1,2,3-triazol-2-yl)phenyl]methyl]-2,7-diazaspiro[3.5]non-7-yl]-2-(2-methylimidazo[2,1-b]thiazol-6-yl)ethanone
纯度： ≥98% (HPLC)
生物活性 for PF 04628935
PF 04628935 is a potent ghrelin receptor inverse agonist (IC50 = 4.6 nM). Orally bioavailable and exhibits reasonable brain penetration.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
化合物库 for PF 04628935
PF 04628935 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for PF 04628935
| 分子量 | 496.03 |
| 公式 | C24H26ClN7OS |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1383719-97-8 |
| PubChem ID | 70682037 |
| InChI Key | MTDYDDJVCIHZKH-UHFFFAOYSA-N |
| Smiles | ClC1=C(CN2CC3(CCN(C(CC4=CN(C=C(C)S5)C5=N4)=O)CC3)C2)C=CC(N6N=CC=N6)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PF 04628935
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 24.8 | 50 | |
| ethanol | 9.92 | 20 |
制备储备液 for PF 04628935
以下数据基于产品分子量 496.03。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.03 mL | 20.16 mL | 40.32 mL |
| 2.5 mM | 0.81 mL | 4.03 mL | 8.06 mL |
| 5 mM | 0.4 mL | 2.02 mL | 4.03 mL |
| 25 mM | 0.08 mL | 0.4 mL | 0.81 mL |
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产品说明书 for PF 04628935
参考文献 for PF 04628935
参考文献是支持产品生物活性的出版物。
Kung et al (2012) Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor. Bioorg.Med.Chem.Lett. 22 5410 PMID: 22677316
If you know of a relevant reference for PF 04628935, please let us know.
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关键词: PF 04628935, PF 04628935 supplier, PF04628935, inverse, agonists, agonism, ghrelin, orally, bioavailable, potent, Ghrelin, Receptors, 6347, Tocris Bioscience
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